Many thanks, Michael!

L

From: freesurfer-boun...@nmr.mgh.harvard.edu 
[mailto:freesurfer-boun...@nmr.mgh.harvard.edu] On Behalf Of Harms, Michael
Sent: 29 September 2015 15:54
To: freesurfer@nmr.mgh.harvard.edu
Subject: Re: [Freesurfer] total grey matter volume


They are conveniently already provided for you in the {lh,rh}.aparc.stats 
files.  And even more conveniently, if you run 'aparcstats2table', with 
--measure=thickness, the last column is the mean cortical thickness (for that 
hemisphere), and if you run with --measure=area, the last column is the total 
white surface area (for that hemisphere).

cheers,
-MH

--
Michael Harms, Ph.D.
-----------------------------------------------------------
Conte Center for the Neuroscience of Mental Disorders
Washington University School of Medicine
Department of Psychiatry, Box 8134
660 South Euclid Ave.  Tel: 314-747-6173
St. Louis, MO  63110  Email: mha...@wustl.edu<mailto:mha...@wustl.edu>

From: <Lim>, Lena <lena....@kcl.ac.uk<mailto:lena....@kcl.ac.uk>>
Reply-To: 
"freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>" 
<freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
Date: Tuesday, September 29, 2015 6:52 AM
To: "freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>" 
<freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
Subject: Re: [Freesurfer] total grey matter volume

Thanks, Michael. How do I get the total thickness and total surface area values 
form Freesurfer/Qdec please?

Thanks again,
L

From: 
freesurfer-boun...@nmr.mgh.harvard.edu<mailto:freesurfer-boun...@nmr.mgh.harvard.edu>
 [mailto:freesurfer-boun...@nmr.mgh.harvard.edu] On Behalf Of Harms, Michael
Sent: 29 September 2015 04:30
To: freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>
Subject: Re: [Freesurfer] total grey matter volume


I'm a fan of using global mean thickness as a covariate for thickness analyses, 
and total surface area as a covariate for surface area analyses.  That way you 
directly covary for possible global effects using the same type of measure that 
you are analyzing.

cheers,
-MH

--
Michael Harms, Ph.D.
-----------------------------------------------------------
Conte Center for the Neuroscience of Mental Disorders
Washington University School of Medicine
Department of Psychiatry, Box 8134
660 South Euclid Ave. Tel: 314-747-6173
St. Louis, MO  63110 Email: mha...@wustl.edu<mailto:mha...@wustl.edu>

From: Doug Greve <gr...@nmr.mgh.harvard.edu<mailto:gr...@nmr.mgh.harvard.edu>>
Reply-To: 
"freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>" 
<freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
Date: Monday, September 28, 2015 11:18 AM
To: "freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>" 
<freesurfer@nmr.mgh.harvard.edu<mailto:freesurfer@nmr.mgh.harvard.edu>>
Subject: Re: [Freesurfer] total grey matter volume


Not for  thickness. For surface area it is a good idea to do some kind of 
normalization. Typically people use the estimated intracranial volume (ICV). 
You can also use total brain volume or total grey volume. You just need to be 
aware that each one of these tests something different.


On 9/28/15 12:15 PM, Lim, Lena wrote:

Dear Experts,

Do we need to include total grey matter volume as a covariate in the freesurfer 
cortical thickness and surface area analyses? I have come across papers that do 
and don't; so I am not sure if I have to do that. Please kindly advice.

Many thanks,

Lena






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