Hi Alan - If you were analyzing a volume (or area or length) measure, it'd make sense to include something like ICV. If you're analyzing an anisotropy or diffusivity measure, you wouldn't expect those to be affected my how big the head is.

Best,
a.y

On Sat, 25 Apr 2015, Alan Francis wrote:


Dear Anastasia:

Hope all is well. I have done tracula analysis on 75 brains (HARDI) and I am 
statistically analyzing the data. Do I need to
use ICV as a covariate in my statistical model?

thank you,

Alan
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Alan N. Francis PhD
NIDA T32  Fellow in Drug Abuse & Brain Imaging
Brain Imaging Center
McLean Hospital
Harvard Medical School
115 Mill Street, Belmont, MA 02478
al...@bwh.harvard.edu
afran...@mclean.harvard.edu
                                                                                
                          
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