Hi Jane

we don't really see much blurring of folding patterns with the 
high-dimensional spherical warp so you might as well use them all 
(although there might be issues with memory - perhaps Doug can comment if 
this is still true).

cheers
Bruce


On Wed, 6 May 2015, Jane 
Garrison wrote:

>
> Hi,
>
> I have a question about the utility of the make_average_subject command.
>
> I have a schizophrenia study with 115 subjects and am worried about using the 
> Freesurfer average brain, given that scz patients have distinct morphological 
> aspects to their brains. I am therefore considering making an average brain 
> from my subjects, but have read some old posts cautioning against this, since 
> an average brain taken across a large number may be too indistinct to be of 
> value.
>
> Is there a recommendation on this - should I produce an average across all my 
> subjects, or should I maybe use a small (20?) sample of my subject brains to 
> create an average?
>
> Thanks so much
>
> Jane.
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>
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