Hi Las

can you send us a couple of images of the problems you are seeing?

cheers
Bruce
On Mon, 7 
Jul 2014, Las Blawimo wrote:

> Dear FreeSurfer Experts,
> 
> 
> We are collecting a 0.9mm isotropic FSPGR sequence on a GE MR750 3T scanner.
> We're observing, in many subjects, a problem mentioned in previous posts to
> the list where the pial surface does not follow the cortex properly in the
> anterior temporal lobe region (and also in some frontal regions). The white
> matter surface generally looks very good. This is with the default options
> from recon-all in v5.3.
> 
> We've also tried running the following options, based on previous posts
> (expert options) and the release notes for version 5.2:
> 
> -norm2-b 20 -norm2-n 5
> 
> and
> 
> -norm2-b 20 -norm2-n 5 -3T
> 
> In general, there is a modest improvement in the medial temporal lobe pial
> surface in most subjects. A substantial/desired improvement is observed in
> only a few subjects. In general, there was no detrimental effect to either
> the white matter or pial surface when using these flags.
> 
> Based on older posts to the list, we've also tried using the following
> flags:
> 
> -mprage
> 
> and
> 
> -washu_mprage
> 
> The improvement to the pial surface is much more substantial in almost all
> subjects, to some extent with the -mprage flag, mostly with the
> -washu_mprage flag. However, this dramatic improvement in pial surface
> accuracy was accompanied by many major issues with the white surface in
> widespread areas across the brain. Also, some subjects fail to reconstruct
> fully due to large defects in the surfaces with this option in place (also
> something I've read about happening to people using the -washu otpion on the
> list).
> 
> A few questions:
> 
> Would you suggest we also try the options "-norm1-b" and "-norm1-n" in
> addition to the norm2 options? If so, any suggested starting values to try?
> 
> Alternatively, would it be sensible to try to use the white surface from the
> default pipeline and combine it with (or perhaps initialize) the pial
> surface from the -washu_mprage flag?
> 
> Do you have other suggestions for us to try?
> 
> Thank you for your time and help!
> 
> Sincerely,
> 
> Las
> 
>
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