Dear Doug,
Thank you for your instantaneous response!
Correcting for disease burden was actually a reviewer
comment.
We calculated mean
cortical thickness estimates for regions that showed vertex-wise age-related
cortical thickness differences between groups (using qdec) and then graphed out
the slope aging-patterns between normal controls and patients, by extracting
the data into SPSS. Basically, our findings indicated that for selected
regions, the patients showed a steeper age-related decline.
It was suggested by the reviewer to correct the correlation
between age and cortical thickness for disease burden in the patient group
(using partial correlations in SPSS).
Would this be an alternative way? It would sure safe us from
re-running our data:)
Very Best Regards,
Catherine
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