Hi Doug and Freesurfers,

I would like to calculate percent signal change within an anatomical ROI
for a group of subjects in Freesurfer 5.0. We are not functionally
constraining our ROI, however, we do want to calculate the percent signal
change across the entire region in each of our conditions (the contrasts
we are using are condition-vs-fixation). Below are examples of the
commands I've run for one of our conditions:

funcroi-config -analysis SIRP_Stable5 -label lh.7Network_6.PFC.label -roi
/cluster/roffman/users/Stable5_PerRun/ROI_Analysis/FB12/Anatomical_roicfg_103113/SIRP_lh_7Networks_6_PFC.roicfg

funcroi-sess -roi
/cluster/roffman/users/Stable5_PerRun/ROI_Analysis/FB12/Anatomical_roicfg_103113/SIRP_lh_7Networks_6_PFC.roicfg
-sf
/cluster/roffman/users/Stable5_PerRun/Subject_Files/30_ActiveFolateAndPlacebo_PostPrePAIRED

funcroi-table-sess -roi
/cluster/roffman/users/Stable5_PerRun/ROI_Analysis/FB12/Anatomical_roicfg_103113/SIRP_lh_7Networks_6_PFC.roicfg
-sf
/cluster/roffman/users/Stable5_PerRun/Subject_Files/30_ActiveFolateAndPlacebo_PostPrePAIRED
-o
/cluster/roffman/users/Stable5_PerRun/ROI_Analysis/FB12/Anatomical_roicfg_103113/18ActiveFolate_12Placebo_PreAndPost_7Tpost/lh_7Networks_6_PFC_1vFix
-c Cond1vFix

Is it necessary to now generate the mean functional baseline offset value
within the ROI in order to calculate percent signal change if our contrast
is comparing condition-vs-fixation? Any clarification on when the offset
value is needed would be greatly appreciated!

Thanks,
Alex



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