Hi Bruce,

I did that test some time ago (each sequence alone or averaged) but  
only with one control subject. I then checked the values of different  
measures and the cortical thickness maps for each situation and they  
were very similar indeed. I did it only with one subject because the  
point was to choose one of the MPRAGEs. But now that I need to drag  
conclusions I wasn't sure if the different sequences would be a major  
problem and would invalidate the conclusions.

I'll match the number of subjects for each sequence but bearing in  
mind that I have two different sequences anyway.


Thank you for the help!

Andreia


Quoting Bruce Fischl <fis...@nmr.mgh.harvard.edu>:

> p.s. you would be better off if you had the same proportion of  
> patients and controls with each sequence. Matching the numbers  
> within one sequence and not the other doesn't really help
>
> On Thu, 28 Mar 2013, _andre...@sapo.pt wrote:
>
>> Hello list,
>>
>> I have a group of subjects (4 patients  and 8 controls) in which one
>> MPRAGE sequence was used and another group of subjects (2 patients and
>> 2 controls) where a diffent MPRAGE was used. Both groups were acquired
>> in the same scanner. For each subject I have two anatomical sequences
>> and I'm working with the average dataset. My question is can I put
>> both groups together for comparision?
>>
>> I've thought about this and I can't really be sure... I was thinking
>> that since for group 2 the number of acquisitions is balanced maybe
>> the overall impact of different sequences won't be significative...
>> Patients and subjects are age-matched in both groups.
>>
>> Please, any advice will be greatly appreciated!
>>
>> Thank you!
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