Hi Andrew,
I don't know how the sulc measure gets computed and what it means
exactly. Probably someone else can tell.
The longitudinal treatment is identical as for example thickness. The
slope (rate) is a fit into the data across time. So a negative slope
means a reduction in whatever is measured. Once you find out what
exactly that measurement describes, you'll know what a smaller value of
that measurements means. Sorry, I can't be of more help.
Best, Martin
On 02/21/2013 12:14 PM, O'Shea,Andrew wrote:
Hello,
I was wondering if I could get some clarification regarding the
longitudinal measure of rate of change in sulci depth. In our study we
have a patient population that participated in an intervention and a
similar group of wait list controls. We have scans for pre and post
intervention timepoints. I have ran the longitudinal analysis in QDEC
looking at the thickness change measures, however I was also
interested in the sulc measures. I was able to get the analysis to run
with the new measures long.sulc-rate etc. However I am having a hard
time conceptualizing the meaning of the results. Does a negative rate
change indicate either a deepening or a shallowing of the sulci? Is
the opposite the case for gyral regions? Any advice would be greatly
appreciated.
-Andrew
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--
Dr. Martin Reuter
Assistant in Neuroscience - Massachusetts General Hospital
Instructor in Neurology - Harvard Medical School
MGH / HMS / MIT
A.A.Martinos Center for Biomedical Imaging
149 Thirteenth Street, Suite 2301
Charlestown, MA 02129
Phone: +1-617-724-5652
Email:
mreu...@nmr.mgh.harvard.edu
reu...@mit.edu
Web : http://reuter.mit.edu
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