Liz,

a 64bit build is in the works.  in the meantime, you can get a version
of mri_robust_register built for lion (64b) here:

ftp://surfer.nmr.mgh.harvard.edu/pub/dist/freesurfer/misc/macos-lion/

Nick


On Tue, 2012-10-02 at 12:12 -0400, Martin Reuter wrote:
> Hi Liz,
>  
> I have no idea about the progress of FS on 64 bit OSX. I think it
> should be possible to run Linux in a virtual box. Both these questions
> can probably be answered by Nick.
>  
> But I would recommend to first try to use a new version of
> mri_robust_template from our dev version (if it goes through, please
> double check 1 or two cases that the base norm.mgz looks good in the
> base and that all time points are aligned in the long directories). It
> may work as the new version needs less memory and I think 3.5 Gig
> should be enough for 3 time points.
>  
> Nick, can you point Liz to where to download a mac version of the
> mri_robust_template from dev?
>  
> Thanks, Martin
>         ----- Original Message ----- 
>         From: Liz Bowman 
>         To: FreeSurfer List 
>         Sent: Monday, October 01, 2012 10:04 PM
>         Subject: Re: [Freesurfer] More than two time-points in
>         longitudinal base = Memory allocation error?
>         
>         
>         Hi Martin, 
>         
>         
>         Thanks for your reply.
>         
>         
>         My iMac has 14 GB of RAM.  However, the Mac OS version of
>         FreeSurfer is only available as a 32-bit version, and thus any
>         time FreeSurfer requires more than approximately 3.5 GB of
>         memory it will exit with an error.  Are there any plans yet
>         for a 64-bit Mac OS version?
>         
>         
>         I have a number of clinical participants with between 3 and 8
>         scans (timepoints) that I wish to analyse longitudinally.  I
>         have already run the cross-sectional reconstructions,
>         performed the necessary pial and white matter edits and
>         inserted control points, and re-run all the cross sectional
>         reconstructions again to take accounts of the edits.
>         
>         
>         If I cannot now create the template reconstructions in Mac OS
>         with all of my timepoints for all of my participants, what are
>         my options?   
>         
>         
>         Is it possible to run the 64-bit Linux version of FreeSurfer
>         using VirtualBox on my iMac? 
>         
>         
>         Could I then just create the template reconstructions for all
>         my participants using virtualbox linux and return to Mac OS to
>         run the final longitudinal stream on all the participants? I
>         am aware that there are differences in how the 64-bit linux
>         and the 32-bit Mac OS FreeSurfers will approach the analysis,
>         but if I confine my use of the 64-bit Linux to just the
>         creation of the templates for both (clinical and control)
>         groups, then any differences between the systems should not
>         affect the between-group comparisons?
>         
>         
>         I do not have access to an actual Linux system.
>         
>         
>         Best regards,
>         
>         
>         EA Bowman
>         
>         
>         > From: mreu...@nmr.mgh.harvard.edu
>         > To: ea_bow...@hotmail.com
>         > Date: Mon, 30 Jul 2012 18:00:29 -0400
>         > CC: freesurfer@nmr.mgh.harvard.edu
>         > Subject: Re: [Freesurfer] More than two time-points in
>         longitudinal base = Memory allocation error?
>         > 
>         > Hi Liz,
>         > 
>         > you need more memory (see the error message: cannot allocate
>         memory).
>         > 
>         > Best, Martin
>         > 
>         > 
>         > On Mon, 2012-07-23 at 10:21 +1000, Liz Bowman wrote:
>         > > Hello,
>         > > 
>         > > 
>         > > I have several patients scans taken over multiple time
>         points (up to
>         > > nine time points in some patients). I thought I might be
>         able to use
>         > > these to create a base template for longitudinal
>         processing, however
>         > > the process fails and exits with errors if I try to create
>         a base with
>         > > more than two time points from a patient. 
>         > > 
>         > > 
>         > > This is a sample of the error log of the most recent
>         attempt, with
>         > > three timepoints:
>         > > 
>         > > 
>         > > Resolution: 1 S( 128 128 128 ) T( 128 128 128 )
>         > > Iteration(f): 1 -- diff. to prev. transform: 0.876663
>         > > Iteration(f): 2 -- diff. to prev. transform: 0.0148738
>         > > Iteration(f): 3 -- diff. to prev. transform: 0.00156813 <
>         0.01
>         > > :-)
>         > > 
>         > > 
>         > > Resolution: 0 S( 256 256 256 ) T( 256 256 256 )
>         > > Iteration(f): 1 -- diff. to prev. transform: 0.263086
>         > > Iteration(f): 2mri_robust_template(1035) malloc: ***
>         > > mmap(size=262144) failed (error code=12)
>         > > *** error: can't allocate region
>         > > *** set a breakpoint in malloc_error_break to debug
>         > > MRIalloc(256, 256, 256): could not allocate 262144 bytes
>         for 68th
>         > > slice
>         > > 
>         > > 
>         > > Cannot allocate memory
>         > > Darwin 550D-UOM88670.local 10.8.0 Darwin Kernel Version
>         10.8.0: Tue
>         > > Jun 7 16:32:41 PDT 2011;
>         root:xnu-1504.15.3~1/RELEASE_X86_64 x86_64
>         > > 
>         > > 
>         > > recon-all -s KSx3 exited with ERRORS at Mon Jul 23
>         10:15:13 EST 2012
>         > > 
>         > > 
>         > > For more details, see the log
>         > >
>         file /Applications/freesurfer/subjects/KSx3/scripts/recon-all.log
>         > > To report a problem, see
>         > > http://surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
>         > > 
>         > > 
>         > > I would be grateful for any advice.
>         > > 
>         > > 
>         > > Regards,
>         > > 
>         > > 
>         > > EA Bowman
>         > > 
>         > > 
>         > > 
>         > > 
>         > > _______________________________________________
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>         > > Freesurfer@nmr.mgh.harvard.edu
>         > >
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>         > 
>         > 
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