Hi Daniel

those are pretty big differences in flip angle. I'll cc Andre van der Kouwe on this so he can comment, but I would be hesitant. The increased TE will have a big effect on dura (darkening it), but will also reduce gray/white contrast.

cheers
Bruce


On Fri, 17 Aug 2012, Daniel Ferreira wrote:

Dear all,
We are designing a study based on clinical data. We want to work with a
MPRAGE sequence but subjects have been given 4 different sets of parameters:

- TR: 1900; TE: 4,38; TI: 1100; flip angle: 15
- TR: 1900; TE: 3,55; TI: 1100; flip angle: 15
- TR: 1900; TE: 3,39; TI: 900; flip angle: 9
- TR: 1900; TE: 3,39; TI: 900; flip angle: 15

I wonder how these differences could affect the images and thus the results.
Can I combine all of them or at least some of them? Are they so different
that I should just study them by separate?

thank you very much on advance

Daniel Ferreira

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