Hi, I am comparing a group of patients with controls. I extracted: > cortical volume, surface area, cortical thickness and gyrification > index for each subject's lobe. > Comparisons between this variables with Total Intracranial Volume as a > covariate indicated a difference in frontal and temporal lobes lGI. >
what happens if you do not adjust for intracranial volume? if your patients have abnormal sized lobes then this may be obscured by controlling for head size. > However, differences were not significant for any of the other > variables. > > I can´t understand these results from a biological perspective. I was > expecting that if a difference exist in lGI it would also manifest in > surface area or volume. > this paper: http://www.ncbi.nlm.nih.gov/pubmed/18267953 tells us that it is possible for smaller sized brains to have higher folding compared to bigger sized brains. however, it also states that it's much more probable for bigger sized brains to have a higher degree of folding, indeed a strong relationship is shown between brain volume, cortical surface and folding (Figs. 3 and 4c) over large parts of the cortex. hth, -joost > Can someone help me with an explanation for this? > > Thank you. > > ines > > _______________________________________________ > Freesurfer mailing list > Freesurfer@nmr.mgh.harvard.edu > https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer > > > The information in this e-mail is intended only for the person to whom it > is > addressed. If you believe this e-mail was sent to you in error and the > e-mail > contains patient information, please contact the Partners Compliance > HelpLine at > http://www.partners.org/complianceline . If the e-mail was sent to you in > error > but does not contain patient information, please contact the sender and > properly > dispose of the e-mail. > >
_______________________________________________ Freesurfer mailing list Freesurfer@nmr.mgh.harvard.edu https://mail.nmr.mgh.harvard.edu/mailman/listinfo/freesurfer The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
