Hi Gabriela
it's hard to get a stable ICV measure from only a T1-weighted image,
since you can't really distinguish bone from air. You can use supra
tentorial, but you are testing a slightly different hypothesis (i.e. that
hippocampal volume is changing faster than supratentorial volume).
cheers
Bruce
On Fri, 30 Mar 2012, HOSSU
Gabriela wrote:
Dear all,
I am working with FreeSurfer version 5.10 from 2 months. I am interested in
hippocampus volume measurements and I want to normalize them with the
intracranial volume.
We have scanned about 4 times the same 2 healthy subjects (3T GE HDxt, 8
channel coil). 3D acquisitions were made with the BRAVO GE sequence in
coronal and sagittal planes (roughly with the same parameters) .
On the hippocampus we obtained about 5% intra subject variation but for the
ICV intra subject variation is around 15%.
With the supra tentorial volume estimations, the variation is around 2%.
Any idea to explain this so important difference for the ICV estimation?
Can we use the supra tentorial volume in order to normalize our hippocampus
estimations?
Thanks,
Gabriela HOSSU, Ph.D.
Chef de projet
CIC-IT Nancy (Inserm CIT801)
CHU de Nancy Brabois
4ème étage Tour Drouet
Rue du Morvan
54511 VANDOEUVRE-LES-NANCY
FRANCE
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