Hi Shahin, there are several ways to answer this question. If you are 
going to analyze assuming a shape to the HRF, then the actual delay 
between stimuli is technically not important (though 4s will be good to 
avoid attenuation in the following stimulus). If you're using an FIR 
model of the HRF (no assumed  shape), then I usually advise that you 
have, in total, as much time spent on fixation (or whatever your null 
stimulus is) as you have for any other stimulus. You can use optseq to 
compute the actual schedule.
doug

SHAHIN NASR wrote:
> Hi Surfers,
>
>    It is my first experience with Event-related paradigms. In my 
> experiment, trials take minimum 6s (TR=2s). I wonder what is the 
> optimum variable delay between trials to be able to analyze data 
> without any confound.
>
> Regards
>
> -- 
> Shahin Nasr
>
> PhD in Cognitive Neuroscience
> Martinos Imaging Center, MGH
> Harvard Medical School
>

-- 
Douglas N. Greve, Ph.D.
MGH-NMR Center
gr...@nmr.mgh.harvard.edu
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