Hi Jordan,
I just had a similar discussion (off-list) with Nick recently.
The distinction only matters if you end up trimming cerebellum voxels
out of the aseg, and want your aseg for cerebellum to be correct.

Quoting Nick:
"it [brain.finalsurfs.manedit.mgz] is used only in the instance (which
has happened only once recently)
where the pial surface extends into the cerebellum.   in this case, you
wouldnt want to trim away the cerebellum in brainmask.mgz, because then
the cerebellum segmentation wont be correct in the aseg (or worst case
the alignment to the atlas wont not be optimal).  so we decided to add
editing of brain.finalsurfs.manedit.mgz, since this is downstream of the
aseg and is input to surface creation. 

End Quote

Edits to brainmask.mgz still get applied, and if all you are doing is
looking at cortical thickness, then you shouldn't need to do redo
anything.

cheers,
-MH


On Fri, 2011-11-18 at 11:55 -0800, Jordan Pierce wrote:
> We've been manually editing brainmask.mgz to remove voxels that are
> included in the pial surface that shouldn't be, and recently found on
> the wiki that to remove cerebellum voxels we should be editing
> brain.finalsurfs.manedit.mgz instead.  What is the reason for this
> difference? Do we need to redo edits that we've done only on
> brainmask.mgz?  We are going to be looking at cortical thickness.
> 
> 
> Thanks,
>  
> Jordan Pierce
> Graduate Student
> Behavioral and Brain Sciences Program
> Psychology Department
> The University of Georgia
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