Hi Don

there is a nonlinear offset filter (Fischl and Schwartz, 1999, IEEE PAMI) 
applied during the segmentation process internally, but no filtered images 
are ever written to disk. You can try it out with mri_nlfilter. In general 
I would rather incorporate the information in the filtering into the 
segmentation than have some black box run beforehand that the segmentation 
doesn't know about, but of course that's not feasible for every filter 
under the sun. Whether it will help or not probably depends a lot on the 
quality of the input data.

Let us know how it goes.

cheers
Bruce


On Fri, 14 Oct 2011, MCLAREN, 
Donald wrote:

> Bruce and others,
>
> Are there any spatial filters applied during the segmentation process
> other than a bias field correction? For example, a spatially adaptive
> non-linear means filter (e.g VBM8)?
>
> If not, do you think denoising filters will improve the accuracy
> and/or reduce manual editting?
>
> Thanks.
>
> Best Regards, Donald McLaren
> =================
> D.G. McLaren, Ph.D.
> Postdoctoral Research Fellow, GRECC, Bedford VA
> Research Fellow, Department of Neurology, Massachusetts General Hospital and
> Harvard Medical School
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