Hi Sheeva,
The pial surface is not designed to include the hippocampus and
amygdala.

Quoting from http://www.freesurfer.net/fswiki/FsTutorial/OutputData :

There are regions where the surfaces are not intended to be accurate
that you should be aware of: 

      * Areas around the hippocampus and amygdala. The surfaces will not
        completely include or exclude certain subcortical regions. These
        inaccuracies can be ignored as subcortical regions are excluded
        from the cortical measures and subcortical volume is measured by
        the aseg, not the surfaces. 

cheers,
-MH


On Mon, 2011-09-12 at 17:04 -0400, Sheeva Azma wrote:
> Dear Freesurfer List,
> 
> I am using recon-all to measure cortical thickness in a population of
> Alzheimer's patients and I have noticed that in many patients the pial
> surface does not include the whole brain.  This seems to be because
> there are hippocampal lesions that are dark spots in the image which
> throw off the segmentation.  I have tried adding control points, but
> that is only for the white matter boundary, and so I was wondering if
> you could provide any insight as to how to correct the pial surface so
> that the entire hippocampus is included.  I have attached an example
> image from tkmedit showing the pial and white boundaries.
> 
> Thank you,
> Sheeva Azma
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