Dear All,

We are making Volume-based analyses and I have a few questions. 

1. The SupraTentorial BrainVolume is indicated in the aseg.stats. I found an 
explanation on http://surfer.nmr.mgh.harvard.edu/fswiki/MorphometryStats about 
the SupraTentorial Vol., but checking the formula by summing up Cortex + 
CorticalWhiteMatter + SubCortGray I do not arrive at the exact value of 
SupraTentorial as indicated in the aseg.stats; for some of my subjects this 
value is higher, for some lower. What could cause these differences except from 
differences between voxel-based measures (i.e., SubCortGray) and surface-based 
measures? Is CSF and ventricle volume already subtracted from this value?

Please see below copied the aseg.stats file for one subject: Cortex 
448248.101786 + CorticalWhiteMatter 404368.03125 + SubCortGray 215645 = 
1068261.13. This differs from the supratentorial value indicated in aseg.stats, 
which is 1218507.78.

2. Is it possible to exclude lesions from the volume-based measures by 
incorporating a self-defined lesion mask for each subject? If there are any 
lesions in structures, I would like to subtract lesion volume these structures 
that are listed in aseg.stats.

Best Regards,

Ruthger Righart (PhD)

Institute for Stroke and Dementia Research (ISD)
Klinikum der Universität München
Max-Lebsche-Platz 30
81377 Munich | Germany

ruthger.righ...@med.uni-muenchen.de



# Title Segmentation Statistics 
# 
# generating_program mri_segstats
# cvs_version $Id: mri_segstats.c,v 1.69.2.1 2010/07/26 16:19:29 greve Exp $
# cmdline mri_segstats --seg mri/aseg.mgz --sum stats/aseg.stats --pv 
mri/norm.mgz --empty --excludeid 0 --excl-ctxgmwm --supratent --subcortgray 
--in mri/norm.mgz --in-intensity-name norm --in-intensity-units MR --etiv 
--surf-wm-vol --surf-ctx-vol --totalgray --ctab 
/Applications/freesurfer/ASegStatsLUT.txt --subject 1008 
# 
# SUBJECTS_DIR /Network/Xgrid/freesurfer_M0HL
# subjectname 1008
# Measure lhCortex, lhCortexVol, Left hemisphere cortical gray matter volume, 
225756.920309, mm^3
# Measure rhCortex, rhCortexVol, Right hemisphere cortical gray matter volume, 
222491.181478, mm^3
# Measure Cortex, CortexVol, Total cortical gray matter volume, 448248.101786, 
mm^3
# Measure lhCorticalWhiteMatter, lhCorticalWhiteMatterVol, Left hemisphere 
cortical white matter volume, 198684.625000, mm^3
# Measure rhCorticalWhiteMatter, rhCorticalWhiteMatterVol, Right hemisphere 
cortical white matter volume, 205683.406250, mm^3
# Measure CorticalWhiteMatter, CorticalWhiteMatterVol, Total cortical white 
matter volume, 404368.031250, mm^3
# Measure SubCortGray, SubCortGrayVol, Subcortical gray matter volume, 
215645.000000, mm^3
# Measure TotalGray, TotalGrayVol, Total gray matter volume, 663893.101786, mm^3
# Measure SupraTentorial, SupraTentorialVol, Supratentorial volume, 
1218507.775726, mm^3
# Measure IntraCranialVol, ICV, Intracranial Volume, 1882094.762769, mm^3
# SegVolFile mri/aseg.mgz 
# SegVolFileTimeStamp  2010/12/01 23:41:35 
# ColorTable /Applications/freesurfer/ASegStatsLUT.txt 
# ColorTableTimeStamp 2010/08/15 20:35:08 
# InVolFile  mri/norm.mgz 
# InVolFileTimeStamp  2010/12/01 18:52:15 
# InVolFrame 0 
# PVVolFile  mri/norm.mgz 
# PVVolFileTimeStamp  2010/12/01 18:52:15 
# Excluding Cortical Gray and White Matter
# ExcludeSegId 0 2 3 41 42 
# VoxelVolume_mm3 1 
# TableCol  1 ColHeader Index 
# TableCol  1 FieldName Index 
# TableCol  1 Units     NA 
# TableCol  2 ColHeader SegId 
# TableCol  2 FieldName Segmentation Id
# TableCol  2 Units     NA
# TableCol  3 ColHeader NVoxels 
# TableCol  3 FieldName Number of Voxels
# TableCol  3 Units     unitless
# TableCol  4 ColHeader Volume_mm3
# TableCol  4 FieldName Volume
# TableCol  4 Units     mm^3
# TableCol  5 ColHeader StructName
# TableCol  5 FieldName Structure Name
# TableCol  5 Units     NA
# TableCol  6 ColHeader normMean 
# TableCol  6 FieldName Intensity normMean
# TableCol  6 Units     MR
# TableCol  7 ColHeader normStdDev
# TableCol  7 FieldName Itensity normStdDev
# TableCol  7 Units     MR
# TableCol  8 ColHeader normMin
# TableCol  8 FieldName Intensity normMin
# TableCol  8 Units     MR
# TableCol  9 ColHeader normMax
# TableCol  9 FieldName Intensity normMax
# TableCol  9 Units     MR
# TableCol 10 ColHeader normRange
# TableCol 10 FieldName Intensity normRange
# TableCol 10 Units     MR
# NRows 45 
# NTableCols 10 
# ColHeaders  Index SegId NVoxels Volume_mm3 StructName normMean normStdDev 
normMin normMax normRange  
  1   4     44165    44165.0  Left-Lateral-Ventricle            19.7155    
16.3746     0.0000    89.0000    89.0000 
  2   5      2806     2806.0  Left-Inf-Lat-Vent                 38.3263    
15.7951     0.0000    83.0000    83.0000 
  3   7     13657    13657.0  Left-Cerebellum-White-Matter      81.6728     
7.8804    19.0000   104.0000    85.0000 
  4   8     58247    58247.0  Left-Cerebellum-Cortex            66.2938     
9.3009    14.0000   102.0000    88.0000 
  5  10      7895     7895.0  Left-Thalamus-Proper              85.7346    
10.2295    28.0000   119.0000    91.0000 
  6  11      7039     7039.0  Left-Caudate                      76.7953     
9.8187    43.0000   106.0000    63.0000 
  7  12      9318     9318.0  Left-Putamen                      80.9289     
7.7446    46.0000   105.0000    59.0000 
  8  13      1860     1860.0  Left-Pallidum                    101.4026     
7.2644    68.0000   125.0000    57.0000 
  9  14      3552     3552.0  3rd-Ventricle                     32.3747    
10.6085     7.0000    78.0000    71.0000 
 10  15      5173     5173.0  4th-Ventricle                     26.7739     
9.2009     5.0000    69.0000    64.0000 
 11  16     21267    21267.0  Brain-Stem                        80.5809    
11.2668     0.0000   112.0000   112.0000 
 12  17      4285     4285.0  Left-Hippocampus                  71.2247     
8.9495    37.0000   103.0000    66.0000 
 13  18      2061     2061.0  Left-Amygdala                     70.0988     
7.7635    46.0000    95.0000    49.0000 
 14  24      2125     2125.0  CSF                               45.0837    
14.0328     0.0000    91.0000    91.0000 
 15  26       353      353.0  Left-Accumbens-area               74.6694     
8.4345    36.0000    97.0000    61.0000 
 16  28      3929     3929.0  Left-VentralDC                    91.5580    
11.5144    25.0000   138.0000   113.0000 
 17  30        80       80.0  Left-vessel                       69.7313    
10.6466    44.0000    93.0000    49.0000 
 18  31      3060     3060.0  Left-choroid-plexus               53.4769    
14.2466    16.0000    97.0000    81.0000 
 19  43     41682    41682.0  Right-Lateral-Ventricle           20.2051    
17.6097     0.0000    95.0000    95.0000 
 20  44      2696     2696.0  Right-Inf-Lat-Vent                35.8659    
13.8272     5.0000    82.0000    77.0000 
 21  46     13037    13037.0  Right-Cerebellum-White-Matter     78.5698     
7.4065    15.0000   101.0000    86.0000 
 22  47     63878    63878.0  Right-Cerebellum-Cortex           62.0222     
8.9751     9.0000   114.0000   105.0000 
 23  49      8346     8346.0  Right-Thalamus-Proper             82.2752    
10.6945    17.0000   117.0000   100.0000 
 24  50      6893     6893.0  Right-Caudate                     77.8693    
10.4023    40.0000   107.0000    67.0000 
 25  51      7934     7934.0  Right-Putamen                     82.6062     
7.5576    35.0000   109.0000    74.0000 
 26  52      1465     1465.0  Right-Pallidum                    99.2448     
8.3569    66.0000   125.0000    59.0000 
 27  53      4524     4524.0  Right-Hippocampus                 69.3366     
8.3325    41.0000   100.0000    59.0000 
 28  54      2064     2064.0  Right-Amygdala                    70.9995     
7.2951    46.0000    94.0000    48.0000 
 29  58       495      495.0  Right-Accumbens-area              82.1215     
7.6559    53.0000   102.0000    49.0000 
 30  60      3792     3792.0  Right-VentralDC                   91.5163    
11.6881    35.0000   139.0000   104.0000 
 31  62        60       60.0  Right-vessel                      67.9400    
12.2748    43.0000    95.0000    52.0000 
 32  63      2811     2811.0  Right-choroid-plexus              54.0732    
12.8437    11.0000   105.0000    94.0000 
 33  72         2        2.0  5th-Ventricle                     53.6667    
15.3080    36.0000    63.0000    27.0000 
 34  77     76464    76464.0  WM-hypointensities                77.3176    
11.2567     3.0000   116.0000   113.0000 
 35  78         0        0.0  Left-WM-hypointensities            0.0000     
0.0000     0.0000     0.0000     0.0000 
 36  79         0        0.0  Right-WM-hypointensities           0.0000     
0.0000     0.0000     0.0000     0.0000 
 37  80       176      176.0  non-WM-hypointensities            67.8028     
9.9931    39.0000    87.0000    48.0000 
 38  81         0        0.0  Left-non-WM-hypointensities        0.0000     
0.0000     0.0000     0.0000     0.0000 
 39  82         0        0.0  Right-non-WM-hypointensities       0.0000     
0.0000     0.0000     0.0000     0.0000 
 40  85       279      279.0  Optic-Chiasm                      74.4070    
19.3980    32.0000   121.0000    89.0000 
 41 251       694      694.0  CC_Posterior                     101.0552    
12.4533    53.0000   129.0000    76.0000 
 42 252       314      314.0  CC_Mid_Posterior                 100.2673    
10.3702    63.0000   122.0000    59.0000 
 43 253       341      341.0  CC_Central                       103.2910    
10.9173    68.0000   125.0000    57.0000 
 44 254       354      354.0  CC_Mid_Anterior                  105.7351    
13.7075    66.0000   137.0000    71.0000 
 45 255       780      780.0  CC_Anterior                      106.4097    
12.6707    70.0000   132.0000    62.0000 

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