Hi All,
We've collected 2 MPRAGEs per subject for a study.  This is on a  
Siemens Tim Trio 3T with a 32-channel head coil, 1mm isotropic data.   
The SNR looks pretty good as expected.  I've read in the freesurfer  
archive that it is not necessary to use two MPRAGEs with this high  
quality data, but I'm wondering if there is a drawback to using two  
since we've already got the data on everyone.  I've compared the  
surface reconstruction and segmentation for a few subjects comparing  
one vs. two MPRAGEs and there is very little difference that I can see  
with my naked eye, except that for one subject there were more surface  
corrections needed for the subject without the two averaged together  
as opposed to just using the first image series.

So, I guess what I'm asking is given this quality of data, would one  
recommend systematically using both MPRAGEs since I already have the  
data, using the first MPRAGE alone to decrease chances of blurring, or  
taking an extra step and trying to figure out for each individual  
which has less motion and using that one?  Honestly, the last option  
does not seem to be totally realistic because there is very little  
motion in any of these images that appears subjectively.

Thanks for your help.
Ariel

---------------
Ariel Brown, PhD

Research Fellow
Department of Psychiatry
Mass General Hospital & Harvard Medical School

Visiting Scientist
Department of Brain & Cognitive Sciences
Massachusetts Institute of Technology

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