Hi Pieter, something has gone wrong, but I'm not sure what. The 
smoothing level in the CSD is nan (not-a-number). Can you tar up the 
glmdir and drop it to me at the file drop address at the end of this email?

doug

Pieter van de Vijver wrote:
>
> /Sorry if I'm posting double, I had some trouble with my last post and 
> don't know if it is published or not/
>
> Dear Freesurfer experts,
>
>  I’m doing a longitudinal study on cortical thickness and subcortical 
> volumes and got some questions. I used the longitudinal stream for the 
> preprocessing
>
>  
>
> 1.       On cortical thickness, I’m doing a paired analysis as 
> described in https://surfer.nmr.mgh.harvard.edu/fswiki/PairedAnalysis, 
> and then a cluster-wise correction as described in 
> https://surfer.nmr.mgh.harvard.edu/fswiki/FsTutorial/GroupAnalysis, 
> with 5000 simulations instead of 5, and a vertex-wise threshold of 3 .
> But I don’t get the ocn.annot map, instead I get a ocn.mgh and ocn.lut.
>  The CSD file also looks weird (constantly about 150 clusters with max 
> size one or 2) and the resulting cluster.summary also gives a huge 
> list of very small but significant clusters. Am I doing something 
> wrong? How should I go about this? I’m using FS 4.5. Files are 
> included (jpg for sig.mgh and cluster.mgh for negative simulation, 
>  and csd (zipped), summary and simulation log)
>
> 2.       For the subcortical volumetric analysis I use the aseg.stats. 
> Is the ICV a reliable measure to correct for overall brain size? I 
> heard ICV measurements are not very reliable on T1’s (I get a mean of 
> 2,4% decrease over 16 months...). Are other methods preferable to this 
> one. 
>
> 3.       Is there a logic or rule of thumb for choosing the 
> vertex-wise threshold?
>
>  
>
> Thanks for your help!
>
>  
>
> Pieter
>
>
>
>
> ------------------------------------------------------------------------
>
>
> ------------------------------------------------------------------------
>
> ------------------------------------------------------------------------
>
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> Freesurfer@nmr.mgh.harvard.edu
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-- 
Douglas N. Greve, Ph.D.
MGH-NMR Center
gr...@nmr.mgh.harvard.edu
Phone Number: 617-724-2358 
Fax: 617-726-7422

Bugs: surfer.nmr.mgh.harvard.edu/fswiki/BugReporting
FileDrop: www.nmr.mgh.harvard.edu/facility/filedrop/index.html

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