If you're referring to VERTEX-WISE analyses of area and volume, there
are "issues" with the interpretability of those measures.

Don Hagler has posted on this several times.
For example, most recently see:
http://www.mail-archive.com/freesurfer@nmr.mgh.harvard.edu/msg15205.html

cheers,
-MH

On Tue, 2010-10-12 at 18:44 +0800, Jay Ives wrote:
> Hi,
>  
> I am wondering what is going on "under the hood" when one makes a
> choice under the Design tab in the Measure (Dependant Variable) box
> for Measure. For example if one chooses "Volume" instead of Thickness,
> what exactly is being used as volume? Where does the information on
> volume come from? I am hoping the answer will be the volume associated
> with each vertex, but where is this information?
>  
> Thanks....J
>  
>   
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