It's hard to tell from the coronal, but it looks ok. The problem is more 
visible in the sagittal.

doug

Jeff Sadino wrote:
> Hello Doug,
>
> I loaded up the tkregister2 program and I think I see some poor 
> transformations.  I've never really used it before though.  Am I just 
> looking at whether or not the green line lines up with the target 
> image wm?  Can you look at my pictures real quick?  040002_S04_test is 
> from fs4 that is having problems.  040002_S04 is from fs3 and has a 
> good icv value.  Some of the blank spots are from my graphics drivers 
> and unrelated to fs.  tkregister2 also said the determinant of 
> 040002_S04_test was 1.49544.
>
> Martin,
>
> Thank you for the idea.  I did this, and got a much better icv.  On 
> fs3, where the icv was good, the number was 1,767,481.  On fs4, it was 
> 1,302,696.  Using your idea on fs4, it was 1,819,485.
>
> Thank you so much to everyone for your help!
> Jeff
>
> On Thu, Feb 25, 2010 at 8:53 PM, Martin Kavec <martin.ka...@gmail.com 
> <mailto:martin.ka...@gmail.com>> wrote:
>
>     Hi Jeff,
>
>     I see this relatively often. Eventhough the talairach registration
>     is fine, the
>     ICV is underestimated. In this case I take old ICV, which helps.
>
>     mri_segstats --subject $MYSUBJECT --old-etiv-only
>
>     This is in 99% of these cases a cure. This is not just a blind
>     attempt. In
>     these cases I then compare each ICV normalized aseg volume against
>     an age
>     matched group and only if the old-etiv-only ICV gives better
>     estimates I use
>     it.
>
>     Cheers,
>
>     Martin
>
>     On Thursday 25 February 2010 23:05:10 Jeff Sadino wrote:
>     > Thanks Doug.  That is very good news to hear!
>     >
>     > Maybe I spoke too soon about fixing the problem.  I looked at 4 more
>     > subjects, and even though the icv value is unique, its magnitude
>     seems
>     > wrong.  Often times, it is smaller than the BrainSegVol, which
>     doesn't make
>     > much sense and it is also low overall.
>     >
>     >
>     > # subjectname 090167_F01
>     > # Measure BrainMask, BrainMaskNVox, Number of Brain Mask Voxels,
>     1639959,
>     > unitless
>     > # Measure BrainMask, BrainMaskVol, Brain Mask Volume,
>     1639959.000000, mm^3
>     > # Measure BrainSegNotVent, BrainSegVolNotVent, Brain
>     Segmentation Volume
>     > Without Ventricles, 1289194.000000, mm^3
>     > # Measure BrainSeg, BrainSegNVox, Number of Brain Segmentation
>     Voxels,
>     > 1299686, unitless
>     > # Measure BrainSeg, BrainSegVol, Brain Segmentation Volume,
>     1299686.000000,
>     > mm^3
>     > # Measure IntraCranialVol, ICV, Intracranial Volume,
>     1105595.114652, mm^3
>     >
>     > # subjectname 090182_S01
>     > # Measure BrainMask, BrainMaskNVox, Number of Brain Mask Voxels,
>     1599981,
>     > unitless
>     > # Measure BrainMask, BrainMaskVol, Brain Mask Volume,
>     1599981.000000, mm^3
>     > # Measure BrainSegNotVent, BrainSegVolNotVent, Brain
>     Segmentation Volume
>     > Without Ventricles, 1199694.000000, mm^3
>     > # Measure BrainSeg, BrainSegNVox, Number of Brain Segmentation
>     Voxels,
>     > 1205382, unitless
>     > # Measure BrainSeg, BrainSegVol, Brain Segmentation Volume,
>     1205382.000000,
>     > mm^3
>     > # Measure IntraCranialVol, ICV, Intracranial Volume,
>     1114008.197334, mm^3
>     >
>     > # subjectname 090187_F01
>     > # Measure BrainMask, BrainMaskNVox, Number of Brain Mask Voxels,
>     1826694,
>     > unitless
>     > # Measure BrainMask, BrainMaskVol, Brain Mask Volume,
>     1826694.000000, mm^3
>     > # Measure BrainSegNotVent, BrainSegVolNotVent, Brain
>     Segmentation Volume
>     > Without Ventricles, 1381871.000000, mm^3
>     > # Measure BrainSeg, BrainSegNVox, Number of Brain Segmentation
>     Voxels,
>     > 1388801, unitless
>     > # Measure BrainSeg, BrainSegVol, Brain Segmentation Volume,
>     1388801.000000,
>     > mm^3
>     > # Measure IntraCranialVol, ICV, Intracranial Volume,
>     1307759.303915, mm^3
>     >
>     > # subjectname 100014_F01
>     > # Measure BrainMask, BrainMaskNVox, Number of Brain Mask Voxels,
>     1948121,
>     > unitless
>     > # Measure BrainMask, BrainMaskVol, Brain Mask Volume,
>     1948121.000000, mm^3
>     > # Measure BrainSegNotVent, BrainSegVolNotVent, Brain
>     Segmentation Volume
>     > Without Ventricles, 1467582.000000, mm^3
>     > # Measure BrainSeg, BrainSegNVox, Number of Brain Segmentation
>     Voxels,
>     > 1488088, unitless
>     > # Measure BrainSeg, BrainSegVol, Brain Segmentation Volume,
>     1488088.000000,
>     > mm^3
>     > # Measure IntraCranialVol, ICV, Intracranial Volume,
>     1637915.031593, mm^3
>     >
>     > # subjectname 040002_S04_test
>     > # Measure BrainMask, BrainMaskNVox, Number of Brain Mask Voxels,
>     1774481,
>     > unitless
>     > # Measure BrainMask, BrainMaskVol, Brain Mask Volume,
>     1774481.000000, mm^3
>     > # Measure BrainSegNotVent, BrainSegVolNotVent, Brain
>     Segmentation Volume
>     > Without Ventricles, 1288022.000000, mm^3
>     > # Measure BrainSeg, BrainSegNVox, Number of Brain Segmentation
>     Voxels,
>     > 1312132, unitless
>     > # Measure BrainSeg, BrainSegVol, Brain Segmentation Volume,
>     1312132.000000,
>     > mm^3
>     > # Measure IntraCranialVol, ICV, Intracranial Volume,
>     1302696.178406, mm^3
>     >
>     > I had also done 040002_S04 in fs 3.0.5, and this is the result:
>     > # subjectname 040002_S04
>     > # BrainMaskFile mri/brainmask.mgz
>     > # BrainMaskFileTimeStamp 2008/29/08 15:44:46
>     > # Measure BrainMask, BrainMaskNVox, Number of Brain Mask Voxels,
>     1753272,
>     > unitless
>     > # Measure BrainMask, BrainMaskVol, Brain Mask Volume,
>     1753272.000000, mm^3
>     > # Measure BrainSeg, BrainSegNVox, Number of Brain Segmentation
>     Voxels,
>     > 1310474, unitless
>     > # Measure BrainSeg, BrainSegVol, Brain Segmentation Volume,
>     1310474.000000,
>     > mm^3
>     > # Measure IntraCranialVol, ICV, Intracranial Volume,
>     1767481.547316, mm^3
>     >
>     > All of the values are similar except the icv.  Do you guys have
>     any ideas
>     > where I can look for the answer?
>     >
>     > Thank you very much,
>     > Jeff
>     >
>
>

-- 
Douglas N. Greve, Ph.D.
MGH-NMR Center
gr...@nmr.mgh.harvard.edu
Phone Number: 617-724-2358 
Fax: 617-726-7422

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