Here is an approach that will be easier, and involves less back and
forth between the surface and volume-based streams (and thus should be
more accurate):  Just use 'mris_volume' to get the volume of everything
enclosed by the pial surface, which if I recall correctly will include
the lateral ventricles, choroid plexus, and usually most of the inferior
lateral ventricles (but not the 3rd and 4th ventricles).  Then, if you
want to exclude ventricles from your definition of "brain volume", just
subtract the Lateral-Ventricle, choroid-plexus, and Inf-Lat-Vent volumes
(taken from the aseg.stats).

cheers,
Mike H.


On Fri, 2010-01-08 at 15:13 -0500, Xiangchuan Chen wrote:
> Dear FreeSurfer experts,
> 
> After searching on FreeSurfer wiki and mailing list, I know that the ICV
> reported in aseg.stats is an estimated value based on talairach
> transformation. So, if the talairach transformation for a subject's head is
> not good, the ICV for this subject is not accurate, am I right?
> 
> If this is the case, it may not be suitable to use ICV to adjust the
> volumetric data in aseg.stats and ?h.aparc.stats for some special subjects.
> I am thinking of using "brain volume" for this purpose. Here are the steps
> to get it:
> 
> 1. Get the surface-based volume of cerebral white matter (aseg.stats).
> 
> 2. Add up the volumes of all cortical regions to get the surface-based
> volume of cerebral cortex (aparc.stats).
> 
> 3. Add up the above volumes (including both hemispheres) and the volumes of
> all other regions listed in aseg.stats (except for cerebral white matter and
> cerebral cortex) to get the brain volume.
> 
> Is this a suitable way to obtain more accurate brain volume?
> 
> Thanks in advance and any suggestions are greatly appreciated,
> 
> Xiangchuan Chen
> 
> 
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