yes, it's definitely not recommended.
On Tue, 20 Oct 2009, Narly A Golestani 
wrote:

>
> Hello all,
>
> I would like to know whether the T1 parameters such as TR, TE, TI, and
> flip angle can systematically influence mean curvature values obtained by
> recon-all -all.
>
> I have processed 2 data sets with the following T1 parameters, and am
> noticing that the mean curvature values systematically bigger in the
> former compared to the latter data set in 78% of the brain regions
> segmented in the default (Desikan) atlas.
>
> data set 1:
> TR=12.24, TE=3.56, TI=530.00, flip angle=23.00
> Original Data has (1, 1, 1) mm size and (240, 256, 176) voxels
>
> data set 2:
> TR=20.66, TE=8.42, TI=640.00, flip angle=25.00
> Original Data has (1, 1, 1) mm size and (224, 256, 176) voxels
>
> More generally, I would like to confirm that it's not recommended to
> combine data based on different scanning parameters in one study, due to
> possible systematic differences in the segmentation output related to
> scanning parameters.
>
> thanks in advance and all the best,
> Narly.
>
>
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