Dear all,

I have a few questions about stats in freesurfer that I'd be very grateful
if you could answer.

1. Is it possible to reduce the search from the whole brain to a smaller
region of interest to apply corrections for multiple comparisons? For
example, if I'm interested in differences in the fusiform gyrus, can I
restrict the FDR correction to the fusiform?

2. Is it important to control for any global measure when comparing
cortical thickness? For example when comparing grey matter volume, it's
good practice to control for the intracranial volume. In case of cortical
thickness (and other dependent measures in freesurfer), do you know how
these are affected by the intracranial volume (or other measures) and how
these could be controlled?

3. Finally, I posted a question a few days ago about comparing volume
using freesurfer. I'm sorry for insisting on this but I still haven't
found any response. My question was whether it's possible to compare
volume maps in freesurfer. I'm using an older version (4.0.4) and my
impression is that the most recent version might have this feature, but
this is unclear to me. I'd be very grateful if you could let me know if
this is the case. And if there's any way in which I can compare volumes
usig data pre-processed using the version I have.

Thank you very much!

Best wishes,

Lucia



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