Did you explicitly check the quality of talairach_with_skull.lta?
Also, what version of FS are you using?

We previously had encountered that error in 5 brains processed under FS
4.0.2, and all five of those had errant talairach_with_skull.lta
transforms.  Generation of talairach_with_skull.lta was made more robust
in FS 4.0.3, and indeed, using v4.0.5, we were able to process all 5 of
our problem brains successfully.

cheers,
Mike H.

On Fri, 2008-08-08 at 21:57 -0400, Bruce Fischl wrote:
> hmmm, that's interesting. If you send us the data we'll take a look. In 
> any case, you can run, if you create an orig_stripped.mgz you can run:
> 
> mri_mask T1.mgz orig_stripped.mgz brain.mgz
> 
> 
> then you should be able to run from after the skull stripping forward 
> (check the recon-all help. You'll need to run a couple of steps before 
> autorecon2-wm and autorecon3).
> 
> cheers
> Bruce
> 
> On Fri, 8 Aug 2008, Vina Goghari wrote:
> 
> > Hi all,
> > I get this error for one subject: mri_watershed Error:
> > GLOBAL region of the brain empty !
> >
> > I check the talairach transformation and it looked good. I also tried just 
> > scripting the orig.mgz and I get a wonderful strip. How can I move forward 
> > with the recon-all process?
> >
> > Thanks,
> > Vina
> >
> >
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> >
> >
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