> Does it mean that C-M-x is different than loading?

Yes.

> Or C-x C-e, for that matter?

As well.

> Is this covered by the manual?  (If not, it might need correcting.)

Not really.  The basic idea is that macroexpansion can take place
*anytime* (tho, before the code is actually executed).  If you care
about when expansion takes place you probably have a bug.


        Stefan


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