Still looking for some feedback. :)
In the meantime I've collected a few links that might be useful for
others with the same questions:

http://www.egenix.com/library/presentations/EuroPython2008-Designing-Large-Scale-Applications-in-Python/
http://highscalability.com/ebay-architecture
http://highscalability.com/
http://www.infoq.com/articles/ebay-scalability-best-practices
http://highscalability.com/unorthodox-approach-database-design-coming-shard
http://www.scribd.com/doc/429986/Scaling-an-early-stage-startup
http://www.coggeshall.org/resources/slideshow/id/530124
http://www.slideshare.net/directi/building-a-scalable-architecture-for-web-apps?src=embed
http://www.slideshare.net/davemitz/7-stages-of-scaling-web-applications
http://www.facebook.com/note.php?note_id=39391378919

2B
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