Definitely not the anomalous map, but that would have been a nice easy fix!


Dr Catherine R. Back (she/her)

Senior Post-doctoral Research Associate

School of Biochemistry

University of Bristol

UK


[email protected]


________________________________
From: Eleanor Dodson <[email protected]>
Sent: 05 September 2025 11:08
To: Catherine Back <[email protected]>
Cc: [email protected] <[email protected]>
Subject: Re: [ccp4bb] Green density over Fe in heme

You are nit accidentally looking at the anomalous difference map are you ?

On Fri, 5 Sep 2025 at 10:39, Catherine Back 
<[email protected]<mailto:[email protected]>>
 wrote:
Good morning,

I am currently solving a structure containing four heme b molecules (res 1.7 
Å), each coordinated by two histidines. The refinement is looking good, but the 
output from refinement has marked the Fe ions of each heme with positive 
density (green) in the FoFc difference map - see image. Any ideas why? I used 
the Monomer Library in Coot to add hemes ('HEM') in. Is it something to do with 
the oxidation state of the Fe? And if so, is there anything I can do about it?

Best wishes,
Catherine


Dr Catherine R. Back (she/her)

Senior Post-doctoral Research Associate

School of Biochemistry

University of Bristol

UK



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