The Role: The Mchaourab laboratory at Vanderbilt University in Nashville, TN is seeking an enthusiastic and diligent postdoctoral fellow to advance our longstanding research on neurotransmitter:sodium symporters (NSSs). This NIH-supported fellowship focuses on evaluating mammalian serotonin transporter (SERT) using electron paramagnetic resonance (EPR) and cryo-EM techniques to explore its conformational dynamics. While experience with membrane transporters is highly valued, EPR and cryoEM training will be provided. The project is central to collaborations with multiple institutions and integrates computational projects within our lab, requiring an individual with excellent communication skills. Salary will adhere to NIH standards and is negotiable based on expertise. The preferred start date is April 2025, but it is flexible.
Qualifications: * A Ph.D. in Biochemistry, Biophysics, or a related field. * Experience with expressing and purifying mammalian membrane proteins. * Experience in X-ray crystallography, cryo-EM, or EPR techniques is preferred. * Strong analytical skills and the ability to think deeply and critically about complex problems. * Excellent organizational skills and attention to detail. * Passion for scientific research and willingness to embrace new challenges. * Ability to work either independently or collaboratively. * Contributes to a positive work environment through actively participating in lab meetings and events. About Us: The Mchaourab laboratory is highly interdisciplinary, utilizing a combination of structural, functional, and computational techniques to explore diverse topics, including conformational dynamics of active transporters and proteostasis in zebrafish, among others. Our experimental expertise is in cryo-EM, EPR, and transport assays. While historically a fully experimental lab, we have embraced the recent revolution in protein structure prediction; we now integrate deep learning methods, such as AlphaFold2, with experimental biophysical approaches to investigate the structure/dynamics/function in multiple classes of transporters. Training in the Mchaourab lab reflects the emerging paradigm of mechanistic structural biology at the interface of computation and experimental sciences. The laboratory is located in the department of Molecular Physiology and Biophysics at Vanderbilt School of Medicine with access to state-of-the-art cores in high performance computing, cryo-EM, EPR, mass spectrometry and various biophysical instrumentation. We are members of the newly inaugurated Center of Applied AI in Protein Dynamics (https://www.vanderbilt.edu/ai-proteindynamics/). If you are interested send CV and letters of recommendation to: Hassane S. Mchaourab, Ph. D., hassane.mchaou...@vanderbilt.edu At Vanderbilt University, we are intentional about and assume accountability for fostering advancement and respect for diversity, and inclusion for all students, faculty, and staff. We have created a community that celebrates differences and lets individuality thrive. As part of this commitment, we actively value all aspects of diversity in our workplace and learning environments as we seek to take advantage of the rich backgrounds and abilities of everyone. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
