The Role:

The Mchaourab laboratory at Vanderbilt University in Nashville, TN is seeking 
an enthusiastic and diligent postdoctoral fellow to advance our longstanding 
research on neurotransmitter:sodium symporters (NSSs). This NIH-supported 
fellowship focuses on evaluating mammalian serotonin transporter (SERT) using 
electron paramagnetic resonance (EPR) and cryo-EM techniques to explore its 
conformational dynamics. While experience with membrane transporters is highly 
valued, EPR and cryoEM training will be provided. The project is central to 
collaborations with multiple institutions and integrates computational projects 
within our lab, requiring an individual with excellent communication skills. 
Salary will adhere to NIH standards and is negotiable based on expertise. The 
preferred start date is April 2025, but it is flexible.

 

Qualifications:

  *   A Ph.D. in Biochemistry, Biophysics, or a related field.

  *   Experience with expressing and purifying mammalian membrane proteins.

  *   Experience in X-ray crystallography, cryo-EM, or EPR techniques is 
preferred.

  *   Strong analytical skills and the ability to think deeply and critically 
about complex problems.

  *   Excellent organizational skills and attention to detail.

  *   Passion for scientific research and willingness to embrace new challenges.

  *   Ability to work either independently or collaboratively.

  *   Contributes to a positive work environment through actively participating 
in lab meetings and events.



About Us:

The Mchaourab laboratory is highly interdisciplinary, utilizing a combination 
of structural, functional, and computational techniques to explore diverse 
topics, including conformational dynamics of active transporters and 
proteostasis in zebrafish, among others. Our experimental expertise is in 
cryo-EM, EPR, and transport assays. While historically a fully experimental 
lab, we have embraced the recent revolution in protein structure prediction; we 
now integrate deep learning methods, such as AlphaFold2, with experimental 
biophysical approaches to investigate the structure/dynamics/function in 
multiple classes of transporters. Training in the Mchaourab lab reflects the 
emerging paradigm of mechanistic structural biology at the interface of 
computation and experimental sciences.



The laboratory is located in the department of Molecular Physiology and 
Biophysics at Vanderbilt School of Medicine with access to state-of-the-art 
cores in high performance computing, cryo-EM, EPR, mass spectrometry and 
various biophysical instrumentation. We are members of the newly inaugurated 
Center of Applied AI in Protein Dynamics 
(https://www.vanderbilt.edu/ai-proteindynamics/).



If you are interested send CV and letters of recommendation to: Hassane S. 
Mchaourab, Ph. D., hassane.mchaou...@vanderbilt.edu



At Vanderbilt University, we are intentional about and assume accountability 
for fostering advancement and respect for diversity, and inclusion for all 
students, faculty, and staff. We have created a community that celebrates 
differences and lets individuality thrive. As part of this commitment, we 
actively value all aspects of diversity in our workplace and learning 
environments as we seek to take advantage of the rich backgrounds and abilities 
of everyone.







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