*Postdoctoral **Position**(s) - Mechanisms of Assemblies Formation
Essential to Muscle Function*
**
EMBL Grenoble specializes in fundamental research in structural biology,
and in developing state-of-the art instrumentation, methods and
services. The site is located on the dynamic European Photon and Neutron
science campus (EPN campus), together with other international and
French research institutions.**
We are recruiting a highly motivated Post-Doctoral Scientist to join the
Head of Unit’s Research Group at EMBL Grenoble, Kristina Djinovic
Carugo. The Djinovic group is interested in the molecular mechanisms
underlying the architecture and assembly of muscle sarcomeres,
particular Z-discs.
The sarcomere - the basic contractile unit of myocytes - assembles from
nascent actin-rich Z-bodies into paracrystalline multiprotein structures
called Z-discs. Yet, the assembly rules and protein components
regulating these complex structures remain largely unknown. We recently
discovered that two main Z-disc proteins form phase-separated liquid
condensates in vitro, which gives rise to the exciting hypothesis that
phase separation is the driving force behind Z-disc assembly by bringing
together its proteins to facilitate interactions.
*Djinovic Group is a member of the collaborative project “From disorder
to order: mechanism of specialised assemblies formation essential for
muscle function” supported by HFSP Award. Its aim is to investigate how
highly ordered sarcomeric Z-disc structure arises from disordered
Z-bodies. We will determine the biophysical and structural principles
underlying sarcomere cytoskeleton assembly in biogenesis, molecular
components, and regulators and integrate the data into a 4D multiscale
integrative molecular model.*
The collaborative team united by HFSP Award will capitalise on
complementary and synergistic expertise in structural biology and
modelling (Kristina Djinovic Carugo, EMBL Grenoble; France and Toshiyuki
Oda, University of Tokyo, Japan), advanced imaging (Jonas Ries,
University of Vienna, Austria) and cardiovascular development and
disease (Travis Hinson, The Jackson Laboratory, Farmington, CT, USA) and
adopt a multifaceted and multiscale approach to tackle the central
questions on sarcomere cytoskeleton assembly in biogenesis at the
molecular and structural level.
*Your role*
You will embark on an exciting journey to decipher the structures of
selected reconstituted complexes and macromolecular condensates using an
integrative structural biology approach, which encompasses molecular
biophysics characterisation, combined with small angles X-ray
scattering, macromolecular crystallography, and cryo-electron
microscopy/tomography, depending on their size and dynamics. As a team
member, you will play a crucial role in uncovering the detailed
biophysical and structural principles that regulate complex assembly.
Joining collaborative efforts, you will contribute to the generation of
a 4D multiscale integrative molecular model.
Apply now
<https://emea3.recruitmentplatform.com/apply-app/pages/application-form?jobId=QHPFK026203F3VBQB688N79SB-6738&langCode=en_GB>
*Closing date:*31 October 2023
* Contract duration: 3 years
* Grading: stipend
* Reference number: GR00215
*Related*
* View all EMBL jobs <https://www.embl.org/jobs/>
* Sign up for job alerts <https://www.embl.org/jobs/alerts>
* View openings from partners <https://www.embl.org/jobs/partners>
*You have*
* PhD degree in a relevant field with strong background in structural
biology.
* Experience in molecular cloning, expression, and purification of
protein complexes is essential.
* Prior knowledge of crystallography and/or single-particle electron
microscopy is needed.
* Track record of writing papers as evidenced by publications or
submitted manuscripts.
* Ability to work independently and also to interact within a group.
* Excellent communication skills, including the ability to write for
publication and present results at scientific meetings.
*You might also have*
* Previous experience in complementary structural biology methods
(e.g. SAXS), molecular and cell biophysics approaches and cell
culture will be considered an advantage.
* Experience with cryo-electron tomography.
* Experience with working in multidisciplinary research teams.
*Why join us*
EMBL is curiosity-driven, community-oriented and international. As an
inclusive, equal opportunity employer, we believe that diversity enables
us to collaborate more effectively and be innovative in our approaches.
We are, therefore, committed to creating an inclusive and flexible
culture - one where everyone can realise their full potential and make a
positive contribution to our organisation.
We encourage applications from individuals who can complement our
existing team – we believe that success is built on having teams whose
backgrounds and personal experiences reflect the diversity of the
populations that our science serves. We actively encourage applications
from all genders and cultures, ethnic groups and all demographics to
help us avoid perpetuating biases and oversights at this
transformational point in our people strategy.
EMBL offers attractive conditions and benefits appropriate to an
international research organisation with a very collegial and
family-friendly working environment. Competitive salary and social
security benefits, financial support for relocation, a relaxed culture,
professional development, canteen and other staff facilities make EMBL a
great place to work.
** Don’t meet every single requirement? We are dedicated to building a
diverse, inclusive and authentic workplace, so if you’re excited about
this role but your past experience doesn’t align perfectly with every
qualification in the job description, we encourage you to apply
nevertheless.
*What else you need to know*
We are Europe’s research laboratory for the life sciences – an
intergovernmental organisation performing scientific research in
disciplines including molecular biology, physics, chemistry and computer
science. We are an international, innovative and interdisciplinary
laboratory with more than 1900 employees from many nations, operating
across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge,
Hamburg, Grenoble and Rome.
Our mission is to offer vital services in training scientists, students
and visitors at all levels; to develop new instruments and methods in
the life sciences and actively engage in technology transfer activities,
and to integrate European life science research. The working language of
the institute is English.
In your online application, you will be asked to include a cover letter,
CV and the contact details of 3 referees.
*Apply here:*
https://www.embl.org/jobs/apply/?jobId=QHPFK026203F3VBQB688N79SB-6738&langCode=en_GB
<https://www.embl.org/jobs/apply/?jobId=QHPFK026203F3VBQB688N79SB-6738&langCode=en_GB>
*Contract duration:*This position is a 3 year contract.
*EMBL is a signatory of DORA.*Find out how we implement best practices
in research assessment in our recruitment processes here
<https://www.embl.org/info/dora/>.
Job advertisements to *Post-Doctoral positions in labs of Travis and
Ries labs* can be found here:
Ries:
Postdoc for super-resolution microscopy of muscle cells
<https://www.maxperutzlabs.ac.at/news/open-positions/l/postdoc-for-super-resolution-microscopy-of-muscle-cells-100325>
Travis:
https://thejacksonlaboratory.wd1.myworkdayjobs.com/en-US/External_JAX/details/Postdoctoral-Associate---Molecular-Biology_JR002268?q=hinson
*Additional Information*
Informal inquiries about this project and position should be sent to
Kristina Djinovic Carugo (kristina.djino...@embl.org), inquiries about
the positions in Hinson and Riels labs to Travis Hinson
(travis.hin...@jax.org) and Jonas Ries (jonas.r...@univie.ac.at).
--
-----
*Kristina Djinovic Carugo*
Head of EMBL Grenoble
European Molecular Biology Laboratory (EMBL) Grenoble
71 Avenue des Martyrs
38000 Grenoble, France
Email:kristina.djino...@embl.org
Website: http://www.embl.fr
Tel:+33 4 76 20 7876; Secretary +33 4 76 20 7123
Mobile: +33 6 60 72 71 61
EMBL_logo
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