We are looking for a highly motivated post-doc to join the Macromolecular Structure group of i3S - Instituto de Investigação e Inovação em Saúde (https://www.i3s.up.pt/research-group?x=113) in Porto, Portugal. The position, funded for 3 years, is expected to start in April 2021.
Building on our recent work (1-5), the project aims to develop direct anticoagulants against alternative targets in the blood coagulation cascade that have not been clinically exploited to date or represent a completely unexplored mechanism of intervention. The successful candidate will investigate the inhibition potency and anticoagulant activities /in vitro/ of potential inhibitors screened by Random nonstandard Peptide Integrated Discovery (RaPID). The candidate will also study the molecular determinants of inhibition, using X-ray crystallography, and perform SAR studies. Finally, the efficacy of lead compounds will be investigated /in vivo/.
The ideal candidate should hold a PhD in Biochemistry, Structural Biology or in a related field, with a good publication record (at least 2 publications as first author in peer-reviewed journals).
Informal enquiries can be addressed to Jorge Ripoll-Rozada (jorge.roz...@ibmc.up.pt <mailto:jorge.roz...@ibmc.up.pt>) or Pedro J.B. Pereira (ppere...@ibmc.up.pt) <mailto:ppere...@ibmc.up.pt)>.
Please note that applications will be considered ONLY if submitted (together with all accompanying documentation) before 2021/03/07, using the online tool at https://www.i3s.up.pt/job-opportunities.php#positions (Position reference: Researcher/FCT_PROJ2020/i3S/1202/2021).
Direct application link: https://dozer.i3s.up.pt/applicationmanagement/#/addapplications/ResearcherFCT_PROJ2020i3S12022021
Further information: https://dozer.i3s.up.pt:8443/fileupload/downloadfile/viewpdfnewtab/50f244dcc6f8b1ecb55beb7ceff2a57 (in Portuguese) or https://dozer.i3s.up.pt:8443/fileupload/downloadfile/viewpdfnewtab/33258f72eae84e385ca4ea1abeb764 (in English).
1- Thompson, R.E.; Liu, X.; Ripoll-Rozada, J.; Alonso-García, N.; Parker, B.L.; Pereira, P.J.B.; Payne, R.J. (2017) Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors. /Nature Chemistry/ *9*, 909-917. DOI: 10.1038/nchem.2744
2 - Watson, E.; Liu, X.; Thompson, R.; Ripoll-Rozada, J.; Wu, M.; Alwis, I.; Gori, A.; Loh, C.-T.; Parker, B.; Otting, G.; Jackson, S.; Pereira, P.J.B.; Payne, R. (2018) Mosquito-derived anophelin sulfoproteins are potent anti-thrombotics. /ACS Central Science/ *4*, 468-476. DOI: 10.1021/acscentsci.7b00612
3 - Watson, E.E.; Ripoll-Rozada, J.; Lee, A.C.; Wu. M.C.L.; Franck, C.; Pasch, T.; Premdjee, B.; Sayers, J.; Pinto, M.F.; Martins, P.M.; Jackson, S.P.; Pereira, P.J.B.; Payne, R.J. (2019) Rapid Assembly and Profiling of an Anticoagulant Sulfoprotein Library. /Proceedings of the National Academy of Sciences of the USA/ *116*, 13873-13878. DOI: 10.1073/pnas.1905177116
4 - Calisto, B.M.; Ripoll-Rozada, J.; Dowman, L.J.; Franck, C.; Agten, S.M.; Parker, B.L.; Veloso, R.C.; Vale, N.; Gomes, P.; de Sanctis, D.; Payne, R.J.; Pereira, P.J.B. (2021) Sulfotyrosine-Mediated Recognition of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological Substrates. /Cell Chemical Biology/ *28*, 26-33. DOI: 10.1016/j.chembiol.2020.10.002
5 - Agten, S.M.; Watson, E.E.; Ripoll-Rozada, J.; Dowman, L.J.; Wu, M.; Alwis, I.; Jackson, S.; Pereira, P.J.B.; Payne, R.J. (2021) Potent trivalent inhibitors of thrombin through hybridization of salivary sulfopeptides from hematophagous arthropods. /Angewandte Chemie International Edition/, in press. DOI: 10.1002/anie.202015127
-- Pedro J. B. Pereira, PhD IBMC - Biomolecular Structure Group i3S - Macromolecular Structure Group Rua Alfredo Allen 208 4200-135 Porto Portugal Tel. +351 226 074 954 E-mail:ppere...@ibmc.up.pt -- Pedro J. B. Pereira, PhD IBMC - Biomolecular Structure Group i3S - Macromolecular Structure Group Rua Alfredo Allen 208 4200-135 Porto Portugal Tel. +351 226 074 954 E-mail: ppere...@ibmc.up.pt ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
