We are looking for a highly motivated post-doc to join the
Macromolecular Structure group of i3S - Instituto de Investigação e
Inovação em Saúde (https://www.i3s.up.pt/research-group?x=113) in Porto,
Portugal. The position, funded for 3 years, is expected to start in
April 2021.
Building on our recent work (1-5), the project aims to develop direct
anticoagulants against alternative targets in the blood coagulation
cascade that have not been clinically exploited to date or represent a
completely unexplored mechanism of intervention. The successful
candidate will investigate the inhibition potency and anticoagulant
activities /in vitro/ of potential inhibitors screened by Random
nonstandard Peptide Integrated Discovery (RaPID). The candidate will
also study the molecular determinants of inhibition, using X-ray
crystallography, and perform SAR studies. Finally, the efficacy of lead
compounds will be investigated /in vivo/.
The ideal candidate should hold a PhD in biochemistry, structural
biology or in a related field, with a good publication record (at least
2 publications as first author in peer-reviewed journals).
Informal enquiries should be addressed to Dr. Jorge Ripoll-Rozada
(jorge.roz...@ibmc.up.pt <mailto:jorge.roz...@ibmc.up.pt>) or Dr. Pedro
J.B. Pereira (ppere...@ibmc.up.pt) <mailto:ppere...@ibmc.up.pt)>.
Applications must be submitted before 2021/03/07 at
(https://www.i3s.up.pt/job-opportunities.php#positions
<https://www.i3s.up.pt/job-opportunities.php#positions>). Reference of
the position: Researcher/FCT_PROJ2020/i3S/1202/2021.
1- Thompson, R.E.; Liu, X.; Ripoll-Rozada, J.; Alonso-García, N.;
Parker, B.L.; Pereira, P.J.B.; Payne, R.J. (2017) Tyrosine sulfation
modulates activity of tick-derived thrombin inhibitors. /Nature
Chemistry/ *9*, 909-917. DOI: 10.1038/nchem.2744
2 - Watson, E.; Liu, X.; Thompson, R.; Ripoll-Rozada, J.; Wu, M.; Alwis,
I.; Gori, A.; Loh, C.-T.; Parker, B.; Otting, G.; Jackson, S.; Pereira,
P.J.B.; Payne, R. (2018) Mosquito-derived anophelin sulfoproteins are
potent anti-thrombotics. /ACS Central Science/ *4*, 468-476. DOI:
10.1021/acscentsci.7b00612
3 - Watson, E.E.; Ripoll-Rozada, J.; Lee, A.C.; Wu. M.C.L.; Franck, C.;
Pasch, T.; Premdjee, B.; Sayers, J.; Pinto, M.F.; Martins, P.M.;
Jackson, S.P.; Pereira, P.J.B.; Payne, R.J. (2019) Rapid Assembly and
Profiling of an Anticoagulant Sulfoprotein Library. /Proceedings of the
National Academy of Sciences of the USA/ *116*, 13873-13878. DOI:
10.1073/pnas.1905177116
4 - Calisto, B.M.; Ripoll-Rozada, J.; Dowman, L.J.; Franck, C.; Agten,
S.M.; Parker, B.L.; Veloso, R.C.; Vale, N.; Gomes, P.; de Sanctis, D.;
Payne, R.J.; Pereira, P.J.B. (2021) Sulfotyrosine-Mediated Recognition
of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological
Substrates. /Cell Chemical Biology/ *28*, 26-33. DOI:
10.1016/j.chembiol.2020.10.002
5 - Agten, S.M.; Watson, E.E.; Ripoll-Rozada, J.; Dowman, L.J.; Wu, M.;
Alwis, I.; Jackson, S.; Pereira, P.J.B.; Payne, R.J. (2021) Potent
trivalent inhibitors of thrombin through hybridization of salivary
sulfopeptides from hematophagous arthropods. /Angewandte Chemie
International Edition/, in press. DOI: 10.1002/anie.202015127
--
Pedro J. B. Pereira, PhD
IBMC - Biomolecular Structure Group
i3S - Macromolecular Structure Group
Rua Alfredo Allen 208
4200-135 Porto
Portugal
Tel. +351 226 074 954
E-mail: ppere...@ibmc.up.pt
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