Dear all

The Microscopy & Microanalysis 2021 meeting will be held in Pittsburgh, 
Pennsylvania, August 1-5. In addition to 4 days of the world's largest 
Microscopy products and services commercial expo hall, M&M 2021 will have over 
1200 platform and poster sessions, Pre-Meeting Congresses, Short Courses, and a 
variety of other workshops, sessions, tutorials, and networking events.  For a 
complete description of the symposium please see the following link: 
https://www.microscopy.org/MandM/2021/meetings/MM2021_CallforPapers.pdf.
 
We would like to invite you to submit an abstract for the Biological Sciences 
Symposium “CryoEM in Drug Discovery”, which will focus on the potential 
applications and uses of cryoEM at the R&D stages of drug discovery. Topics of 
interest are (and not limited to) the use of cryo-EM structures to drive 
structure-based drug discovery, integration of cryoEM and modeling in small 
molecule design and optimization, epitope mapping, methods aimed at optimizing 
(faster, cheaper, better) the process, microED and tomography.  We encourage 
both academic and industrial researchers to submit a paper.  Young researchers 
(students, post-doc and professional technical staff members) can also apply 
for M&M Meeting Awards and memorial awards, which consist of full meeting 
registration and up to $1,000 for travel-related expenses.
 
Among the submitted abstracts 10 will be selected for oral presentations (15 
minutes each with 5 minutes for discussion).  All abstracts can of course be 
part of the poster sessions.
 
Deadline for abstract submission is  February 18, 2021.  Information on how to 
submit the abstract can be found in the meeting homepage 
(https://www.microscopy.org/MandM/2021/) We sincerely hope that you will join 
us at M&M 2021
 
Sincerely
 
Giovanna Scapin
Christel Verboven
Leah Frye
 
B08 - Cryo-EM in Drug Discovery
ORGANIZERS:
Leah Frye, Schrodinger
Giovanna Scapin, NanoImaging Services
Christel Verboven, Thermo Fisher Scientific
 
Recent advances in cryo-EM technology have resulted in the ability to obtain 
structures of pharmaceutically relevant proteins with atomic level resolutions 
in a timely fashion. Importantly, cryo-EM greatly expands the availability of 
structures for large protein assemblies and membrane bound proteins which have 
been difficult to access via X-ray crystallography. This symposium will focus 
on the use of cryo-EM in drug discovery. Presentations will describe projects 
utilizing cryo-EM structures to drive structure-based drug discovery efforts 
for the optimization of potency and selectivity, including selectivity against 
ADMET targets, in projects from both industrial and academic groups.


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