Hello Everyone, We have two open positions in my group available immediately. Feel free to get in touch with any questions or send along a CV & cover letter directly.
TJ Lane Group Leader Center for Free Electron Laser Science --- *Understanding how proteins move by through multi-crystal analysis* Postdoctoral Position Center for Free Electron Laser Science (CFEL), Hamburg, Germany We know proteins make use of long-range motions to perform the essential functions of life: transmit signals, conduct chemistry, and mechanically alter the environment, but how proteins accomplish these amazing tasks remains unexplained at the atomic level. Experimentally measuring these long-range motions at atomic detail has been a challenge. Recently, our group had success in doing this for the main protease (Mpro) from SARS-COV-2, the virus behind the COVID pandemic. Many datasets on COVID and non-COVID proteins have been collected, but new methods are necessary to investigate and extract information about protein motions in these data — we seek a computational scientist to drive this work. As the ideal candidate, you will have the following key attributes: -- A doctoral degree in physics, biophysics, computer science, or a related field -- Excellent computational skills, including python and modern data science methods -- Capabilities in computational crystallography (serial crystallography a bonus but not required) -- Knowledge of the principles of protein structure and function -- The ability to drive your work independently and show initiative And you will be excited to take on the following responsibilities: -- Writing software and scripting to perform data analysis on a daily basis -- Working with large, rich crystallographic datasets from synchrotrons and XFELs -- Analysis/interpretation of experimental data and results -- Helping to foster an environment conducive to collaboration, learning, growth, and fun The position offers a chance to work at a world-leading center in the midst of some of the pioneers of the x-ray laser field. CFEL, DESY, and the broader Science City Bahrenfeld offer an interdisciplinary, collaborative, welcoming, and energizing environment backed by excellently equipped labs, computational and engineering support, and a mindset that no problem is too big to tackle. You will bring your initiative and energy to use these resources and this environment to do great science. Available immediately is a two year contract with the possibility to extend to three years, with a competitive salary and the opportunity to work and live in the vibrant city of Hamburg, Germany. For more details or to apply, write directly to TJ Lane and provide a CV and short introduction or cover letter: <thomas.l...@desy.de> Also see our website: pbio.cfel.de ------------------------------------------------------------------------------------- *Understanding enzyme catalysis by filming enzymes at atomic/fs resolution* Postdoctoral Position Center for Free Electron Laser Science (CFEL), Hamburg, Germany Enzymes are the best performing catalysts on Earth, yet the details of their function — for example what role dynamics play or not in chemical rearrangements — remain a source of debate. New x-ray free electron laser (XFEL) technology allows us to directly image proteins at the time and length-scales (atoms/fs) on which chemistry occurs, making it possible to directly study enzyme catalyzed reactions via imaging. The photobiology group led by TJ Lane at CFEL seeks a postdoctoral candidate to conduct this work on naturally occurring and man-made photoenzyme systems. As the ideal candidate, you will have the following key attributes: -- A doctoral degree in physics, chemistry, biochemistry, or a related field -- Excellent wet-lab skills, with knowledge of how to produce, purify, and crystallize proteins -- A basic familiarity with serial femtosecond crystallography and XFELs -- Basic computational skills including unix-style environments, python/matlab/similar -- The ability to drive your work independently and show initiative And you will be excited to take on the following responsibilities: -- Design of experiments, including new hardware and software when necessary -- Organizing and leading teams of 2-20 people to conduct XFEL experiments -- Preparation of protein crystal samples and wet lab bio/chemistry -- Interpretation and analysis of experimental results -- Helping to foster an environment conducive to collaboration, learning, growth, and fun The position offers a chance to work at a world-leading center in the midst of some of the pioneers of the x-ray laser field. CFEL, DESY, and the broader Science City Bahrenfeld offer an interdisciplinary, collaborative, welcoming, and energizing environment backed by excellently equipped labs, computational and engineering support, and a mindset that no problem is too big to tackle. You will bring your initiative and energy to use these resources and this environment to do great science. Available immediately is a two year contract with the possibility to extend to three years, with a competitive salary and the opportunity to work and live in the vibrant city of Hamburg, Germany. For more details or to apply, write directly to TJ Lane and provide a CV and short introduction or cover letter: <thomas.l...@desy.de> Also see our website: pbio.cfel.de ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
