Dear all,

We are recruiting for a new member of the CCP-EM team:

https://www.harwellhub.com/Jobs/2020/February/Computation-Scientist-CCP-EM-Software-Developer-fo

This is a really exciting software development post working in collaboration 
with Sjors Scheres (MRC-LMB, RELION) and Gerard Bricogne (Global Phasing, 
SHARP, BUSTER, autoPROC and STARANISO).

It is an open-ended (i.e. not fixed-term) staff scientist position based in the 
CCP-EM core team at the Rutherford Appleton Laboratory in Oxfordshire, UK.

A detailed description is given in the link above but feel free to contact me 
directly for any further information or informal enquiries.  Closing date is 
Sunday 29th March.

All the best,

Tom and the rest of the CCP-EM team


----

In collaboration with the Scheres group and Global Phasing we will develop a 
new software framework to combine tools for image processing and 3D volume 
reconstruction in RELION with the existing tools in CCP-EM for model building, 
refinement and validation. This will provide an open API to allow integration 
of third-party algorithms, including software from Global Phasing. This 
pipeline framework will create/enable:

Enhanced on-the-fly processing for use in data acquisition.
Complete data processing pipeline from images to refined atomic models.
Modern and flexible user interface.
Rich metadata capture suitable for internal record keeping, deposition to 
EMDB/PDB, and use in the development of ML-based algorithms.

Specific responsibilities include:

Reviewing existing codebases and investigating use of suitable third-party 
libraries
Designing and implementing new software framework for pipeline
Developing new user interfaces and visualisation tools
Liaising with partners to test framework outputs including: eBIC for on-the-fly 
processing; EBI/EMDB for validation and deposition; STFC Scientific Machine 
Learning Group for use in ML; pharmaceutical licence holders for provision of 
end-to-end pipelines (images to models); Global Phasing for integration of 
external processing routines
Assisting Global Phasing with investigations and implementations of 
Bayesian-based algorithms.

On a day-to-day basis, duties will also include:

Developing and maintaining software architecture
Open communication with collaborators via site visits and video conferencing
Keeping up to date with the latest methodology developments in cryoEM
Presenting work through international meetings and publications.

Please contact Tom Burnley (tom.burn...@stfc.ac.uk) if you have any queries 
about this vacancy.
£38,318 - £46,576/Year

About You

You will be a highly motivated and experienced computational scientist with a 
track record of effective software engineering. Previous experience with Python 
is highly desirable, as is knowledge and experience of cryoEM data processing 
and structural biology.

The post requires extensive interactions with the community of scientists and 
developers, and therefore you need good communication skills and should be 
comfortable making scientific presentations and teaching. This role will also 
require regular travel to other partner sites.




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