Dear All,
We are looking for highly motivated and ambitious individuals to progress
our R&D programme on synthetic viral nanosystems (SVNs), to fill two PhD
posts available: one in next-generation vaccines and one in novel genome
engineering tools. The projects are in the frame of the BBSRC funded
doctoral training programme of the Sout West (SWBio DTP) and underpinned by
the European Research Council (ERC AdG DNA-DOCK) and the EPSRC Innovative
Vaccine Manufacturing and Research Hub.
The posts advertised synergistically combine complementary expertise in the
groups of Imre Berger (Max Planck Bristol Centre for Minimal
Biology), Christiane Schaffitzel (School of Biochemistry and Wellcome GW4
Cryo-EM Centre Bristol), Mark Dillingham (DNA Biology Unit, Bristol
University Bristol) and Frederic Garzoni from Imophoron SARL, an
award-winning vaccine innovator start-up at UnitDX Bristol.
The projects follow from recent discoveries (e.g. Synthetic
self-assembling ADDomer platform for highly efficient vaccination by
genetically encoded multiepitope display, Science Advances, 2019; MultiBac:
Baculovirus-Mediated Multigene DNA Cargo Delivery in Insect and Mammalian
Cells, Viruses 2019; Highly efficient baculovirus-mediated multigene
delivery in primary cells. Nature Communications 2016) and aim to bring
about a step-change in the application of SVNs to combat infectious and
genetic disease.
The successful candidates should have a BSc, MSc or equivalent degree
in synthetic biology, molecular biology, protein biochemistry or related
fields and a strong interest in biodesign, protein engineering,
biochemistry and structural biology. We are looking for a creative and
ambitious person with good communication skills and keen to work on
challenging projects.
The Max Planck Center for Minimal Biology is a joint initiative of the
University of Bristol UK and the Max Planck Gesellschaft, Germany. The
groups involved use synthetic biology, protein engineering, *in vitro*
selection/evolution, cryo-electron microscopy, x-ray crystallography) to
create new vaccines and advanced genome engineering tools.
The groups at Bristol have excellent access to state-of-the-art
synthetic biology technologies including platforms for in vitro
selection/evolution (Ribosome Display) and protein production (MultiBac).
The in house EM facility is equipped with a microscopes including an
Arctica/K2. Additionally, we have access to the Titan Krios microscopes and
the X-ray beamlines at the nearby National Facility at Diamond/Harwell. Other
facilities on the Bristol campus include microfluidics, high performance
computing, high-field NMR and high-throughput crystallization
Biosuite, mammalian
facilities, biophysical platform and confocal microscopy in the Bristol
BioSuite and Wolfson facilities.
Interested and excited? You can find out more about these vacancies here:
https://www.linkedin.com/posts/imre-berger-7a0a6a50_addomer-synthetic-multiepitope-virus-like-activity-6595367002435649536-anJV
https://www.linkedin.com/feed/update/urn:li:activity:6598170469470355456/
or by contacting Imre Berger: imre.ber...@bristol.ac.uk
or Christiane Schaffitzel: christiane.berger-schaffit...@bristol.ac.uk
Please apply online through:
https://www.findaphd.com/phds/project/addomer-synthetic-multiepitope-virus-like-particle-platform-for-next-generation-vaccines/?p108225https://www.findaphd.com/phds/project/precision-genome-editing-using-modulators-of-dsdna-break-repair-pathways/?p114537
Kapil Gupta on behalf of
Prof. Imre Berger PhD HDR FRSB
Founding Director, Max Planck Centre for Minimal Biology
Chair in Biochemistry and University Research Fellow
Wellcome Trust Senior Investigator, ERC Investigator
Co-Director, Bristol Biodesign Institute BBI
Director, BrisSynBio Centre
School of Biochemistry, Faculty of Life Sciences and
Max Planck Bristol Centre for Minimal Biology and
BrisSynBio, an EPSRC/BBSRC Centre for Synthetic Biology
University of Bristol
1 Tankard's Close
Bristol BS8 1TD
Tel: 0044 (0) 117 39 41857
Mobile: 0044 (0) 79 0720 8697
maxplanck-minimalbiology.bristol.ac.uk/
<https://maxplanck-minimalbiology.bristol.ac.uk/>
<http://www.bris.ac.uk/fmvs>
www.bris.ac.uk/biomedical-sciences/ <http://www.bris.ac.uk/fmvs>
www.bristol.ac.uk/research/institutes/biodesign/
www.bristol.ac.uk/brissynbio
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