**PhD student position at the Institute of Protein Biochemistry, Ulm
University (Germany),
Group Prof. Dr. M. Fändrich
The Institute of Protein Biochemistry
(_https://www.uni-ulm.de/nawi/nawi-pbc.html_) investigates the molecular
basis of amyloid diseases, such as Alzheimer's disease and systemic
amyloidosis. We use a broad range of techniques from protein
biochemistry, structural biology (in particular cryo-EM) to cell
biology. Our strong ties to several medical institutions enable us to
uniquely link structural biology with patient and animal samples. We
seek for new doctorate students with a very good Master degree in, for
example, Biochemistry, Chemistry or Physics to strengthen our cryo-EM
analysis of amyloid fibril structures. Projects may involve protein
purification and sample preparation, cryo-EM imaging, single particle
reconstruction, structural modelling and the combination of structural
and biological/medical data.
Recent references:
Cryo-EM fibril structures from systemic AA amyloidosis reveal the
species complementarity of pathological amyloids. Liberta F, Loerch S,
Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC,
Grigorieff N, Fändrich M, Schmidt M. Nature Comm. 10, 1104 (2019)
Cryo-EM structure of a light chain-derived amyloid fibril from a patient
with systemic AL amyloidosis. Radamaker, L, Lin Y-H, Annamalai K, Huhn
S, Hegenbart U, Schönland SO, Fritz G, Schmidt M, Fändrich M. Nature
Comm. 10, 1103 (2019)
If you are interested, please contact us under
bewerbung-pbc(at)uni-ulm.de.Incoming mails will be viewed from July 31st
2019 onwards. Position will be filled as soon as possible.
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