Dear Samuel, I'm guessing you are not constrained by sample availability. Consider a multi-crystal approach to understand your native structure and contrast against structures with low occupancy binders (Pearce et al 2017, https://www.nature.com/articles/ncomms15123 ).
That structure (a pandda ground state model) will be a great place to start a polder map. Jose' === Jose Brandao-Neto MPhil CPhys Senior Beamline Scientist - I04-1 XChem Scientist Diamond Light Source jose.brandao-n...@diamond.ac.uk +44 (0)1235 778506 === ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
