Dr. Julien’s laboratory at The Hospital for Sick Children Research Institute is 
looking for a Computational Biologist to join our Structural Immunology team as 
a Research Associate. The successful candidate will participate in the design 
and engineering of antigens and antibodies in our quest to develop effective 
immunogens and immunotherapies. We are looking for a driven, enthusiastic and 
experienced scientist who demonstrates passion and creativity towards the 
structure/function study of important pathogenic targets and who can thrive in 
a highly-collaborative setting.

Roles & Responsibilities

  *   Use computational biology approaches to design and optimize proteins from 
available antibody-antigen crystal structures;
  *   Apply computational biology to engineer protein nanoparticles with 
optimal delivery properties;
  *   Interact across research teams to enhance computational biology 
applications related to vaccine design and antibody therapeutic development;
  *   Coordinate projects with international collaborators, including timely 
presentation of results and joint writing of reports.

Desired Skills and Experience

  *   Computational/Structural Biologist with a PhD in Computational Biology, 
Biochemistry, Molecular Biology, Immunology, or related field. Post-doctoral 
experience is a plus;
  *   Required expertise in using Rosetta, Haddock, MOE or equivalent software 
for computational modeling and analysis of protein structures, including 
protein design, ligand docking, and structure prediction of proteins;
  *   Demonstrated ability to participate in collaborative and productive 
scientific projects;
  *   Experience in supervising and mentoring junior members of a research team;
  *   Practical experience in using protein evolution or yeast/mammalian 
display approaches to improve antibody-antigen binding interfaces is a plus;
  *   Strong knowledge in using structural biology techniques to study 
pathogens, especially in a context of structure-based vaccine design is a plus;
  *   Experience in molecular biology, protein expression in various systems, 
purification and biophysical characterization is a plus.

How to Apply?
Send your CV and a letter of intent to 
jean-philippe.jul...@sickkids.ca<mailto:jean-philippe.jul...@sickkids.ca> 
before Jan 19th 2018. Successful candidates will be notified for interviews, at 
which time two letters of references will also be required. Anticipated start 
date is February/March 2018.

About Us
Dr. Julien's laboratory is interested in the structure/function study of B cell 
receptors and antibody interactions with antigens. A better understanding of 
the structures of B cell surface molecules and their secreted antibodies will 
serve towards the rational design of improved vaccine immunogens against a 
variety of pathogens, including malaria and HIV-1. Structure-based design is 
also applied to optimize antibody therapeutics to deplete dysregulated B cells 
in blood cancers and autoimmune disorders. Dr. Julien’s laboratory is located 
in The Peter Gilgan Centre for Research and Learning, a new 21-story, 750,000 
square-foot facility that incorporates an open-concept design, state-of-the-art 
research facilities, and collaborative work spaces. As a member of the SickKids 
community, you will become part of a world-renowned organization dedicated to 
fulfilling a vision of Healthier Children, A Better World. For over 135 years, 
SickKids has worked hard to make the world a better place for children and 
their families. Each day, people around the organization are doing meaningful 
work that directly, and often indirectly, benefits children in Canada and 
around the world.


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