Hi Dusan, I tried OCA (http://oca.weizmann.ac.il/oca-bin/ocamain) and entered the keywords: inactive enzyme substrate complex.
I got five hits, including mutants (pdf here attached). Best, Nadir Pr. Nadir T. Mrabet Structural & Molecular Biochemistry N-gere - INSERM U-964 University of Lorraine, Nancy School of Science and Technology and School of Medicine 9, Avenue de la Foret de Haye 54500 Vandoeuvre-les-Nancy, France Tel. (direct) : +33 (0)3.83.68.32.73 Tel. (secretary) : +33 (0)3.83.68.32.92 Cell. : +33 (0)6 11 35 69 09 Fax. : +33 (0)3.83.68.32.79 Email : Nadir.Mrabet <at> univ-lorraine.fr ----- Le 13 Avr 15, à 10:51, dusan turk <dusan.t...@ijs.si> a écrit : > Hello, > I have a dispute with a grant referee about the scientific relevance of > structures of catalytically inactive enzymes including their complexes with > substrates or analogues. I was looking through pdb and the keyword search did > not get me far. Could you please tell me > - which enzyme structure of catalytically inactive mutant was published first > and when > - which catalytically inactive enzyme structure in complex with substrate or > part of it as a ligand was published first and when. > help of the community is highly appreciated, > best wishes, > dusan > Dr. Dusan Turk, Prof. > Head of Structural Biology Group http://bio.ijs.si/sbl/ > Head of Centre for Protein and Structure Production > Centre of excellence for Integrated Approaches in Chemistry and Biology of > Proteins, Scientific Director > http://www.cipkebip.org/ > Professor of Structural Biology at IPS "Jozef Stefan" > e-mail: dusan.t...@ijs.si > phone: +386 1 477 3857 Dept. of Biochem.& Mol.& Struct. Biol. > fax: +386 1 477 3984 Jozef Stefan Institute > Jamova 39, 1 000 Ljubljana,Slovenia > Skype: dusan.turk (voice over internet: www.skype.com
OCA Query Results.pdf
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