Postdoctoral Fellow in Structural Biology and Chromatin Biology: Brighton, United Kingdom
A Postdoctoral Research Fellow position is available in the newly established group of Erika Mancini at the School of Life Sciences, University of Sussex. The successful candidate will join a multidisciplinary group using structural biology, biochemistry, biophysics and cell biology to characterise complexes involved in chromatin remodelling and the regulation of eukaryotic transcription. More information on our research activities is available at the old lab website: (https://www.strubi.ox.ac.uk/research/erika-mancini) The Fellow will benefit from a multidisciplinary environment and a highly collaborative community with particular strengths in cell biology and cancer (including the MRC Genome Damage and Stability Centre). The School of Life Sciences at Sussex is very well equipped for all aspects of modern structural biology, with state-of-the-art facilities for molecular biology, recombinant expression in bacterial and eukaryotic systems, biochemistry, biophysics and X-ray crystallography. Excellent synchrotron access (~ 2 days/month) is available through rolling beam allocation programmes at Diamond and ESRF, and there is a strong existing structural biology activity in the School. You will have, or expect to soon complete, a PhD (or equivalent) in biochemistry, biophysics, molecular biology or related subject. Experience with recombinant DNA techniques, high-quality protein expression and purification for structure-function studies is essential. Experience in crystallization and X-ray crystallography of protein-protein and protein-DNA complexes and biophysical and biochemical assays to characterize protein-protein and protein-DNA interactions is also required. Experience in other structural biology techniques, such as single particle electron-microscopy, SAXS or NMR would be advantageous. Finally, a background in the cell biology of chromatin and transcription regulation would be a strong asset. For more information, including details on how to apply, please visit http://www.sussex.ac.uk/aboutus/jobs/708 . Informal enquiries should be addressed to Dr. Erika Mancini (er...@strubi.ox.ac.uk). Deadline for applications: 5th August 2014
