You are invited to apply for a postdoctoral position in the structural biology lab of McArdle Cancer Institute of University of Wisconsin at Madison. We are interested in understanding the structural basis and mechanisms of cancer-related cell signaling proteins and protein complexes. One important focus of the study is to elucidate mechanisms of protein chaperones in modulating the function of signaling proteins with important relevance to cancer, such as protein phosphatase 2A (PP2A) complexes, viral kinases, and nuclear receptors, using X-ray crystallography and FRET imaging in combination of diverse biochemical, biophysical and cell biology approaches. Some results related to this aspect can be found in our recent publications (Molecular Cell 41, 1–12, 2011; Nat. Commun., 4:1699, 2013; Cell Research, doi:10.1038, 2013).
The lab is equipped with a state-of-the-art setup for x-ray crystallographic studies, including crystallography robot, and advanced imaging system for FRET study in mammalian cells. The researcher will work in a multidisciplinary setup, including cell biology, biophysics, proteomics, and protein biochemistry, in addition to protein crystallography. Candidates should hold a PhD in protein biochemistry and crystallography and have a good working knowledge of molecular biology techniques. Experience in NMR spectrometry is highly appealing. The candidates should be highly motivated, goal-driven, and dedicated individuals who can think critically and work both independently and collaboratively with good verbal and written communication skills. It is also important that the candidates are creative in problem solving and have a strong desire to seek answers to questions related to the molecular basis of cellular processes. Experience in cell culture techniques and writing scientific research papers would be advantageous. Postdoctoral training grant is available for eligible candidates. Eligibility to training grant is appealing, but not essential. This is a full-time position with a starting salary of $39,264 – 44,340 per year depending on skills and experience. Review of applications will begin immediately and continue until the positions are filled. To apply: Please send a cover letter, CV and the names and contact information for three references to Dr. Yongna Xing, 1400 University Avenue, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison-Madison, WI 53706. Email: yx...@oncology.wisc.edu.
