Sent on behalf of Prof. Paul Wyatt…….. Dear all, A position is available for a structural biologist to work within the Drug Discovery Unit at the University of Dundee. Details are outlined below – all applications will be processed through the www.dundee.ac.uk/jobs website quoting reference LS0351 Thanks David Reference Number: LS0351 Job Title: Structural Biologist College: College of Life Sciences School: Life Sciences Research Division: Biological Chemistry and DrugDiscovery Grade: Grade 7 (£29,249 - £35,938) Job Category: Research Closing Date: 20 August 2013 The Drug Discovery Unit (DDU) (see http://www.drugdiscovery.dundee.ac.uk) is a fully integrated drug discovery operation based within a world class Life Sciences research environment. Its remit is to complement BioPharma activities by tackling both neglected diseases (sleeping sickness, leishmaniasis and malaria) and validation of novel targets and mechanisms across a range of potential therapeutics areas. The DDU works to Biotech style philosophy andstandards incorporating, dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria. The project goals are therapeutic area dependent but range from quality leads demonstrating disease model proof of concept, through to pre-clinical candidates. We are looking for a highly motivated structural biologist, to work as part of our drug discovery efforts. The main role will include design of protein constructs, protein expression & purification, crystallisation, solution of x-ray structures and co-crystallisation studies to support in house fragment-based and structure-based drug discovery. We have access to an in-house x-ray diffractometer and to synchrotron sources externally. You will have structure-based drug discovery experience. You will be part of a BioPharma experienced multi-disciplinary team in the DDU, consisting of hit discovery scientists, medicinal chemists, computational chemists and DMPK scientists, as well as structural biologists. The post isavailable immediately. Salary will depend on experience, but will be between £29,249 and £35,938. Your responsibilities: • Contribute to drug discovery projects, through determination of ligand-protein structures and input into the design process. • Fragment-based drug discovery. Knowledge, qualifications, skills and experience: • Candidates must be professionally qualified with a PhD in structural biology. • Expertise in design of protein constructs, protein expression &purification, crystallisation, solution of x-ray structures and co-crystallisation studies to support in house fragment-based and structure-based drug discovery. • A thorough understanding of protein-ligand interactions. • Familiarity and understanding of software related to structural biology. • Understanding and appreciation of the drug discovery process is an advantage • Strong interpersonal, communication and presentation skills • Good time management, organizational and communication skills. A few facts about The College of Life Sciences at Dundee: • The College of Life Sciences has over 900 research and support staff from 59 countries and external funding in excess of £40 million per year • Dundee has twice been named ‘the best place to work in Europe’ in a poll of scientists conducted by The Scientist magazine • The College of Life Sciences has been consistently rated ‘5-star’ (the highest rating) by the UK national Research Assessment Exercise. Dundee, set on the east coast of Scotland, lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills. How to apply: To apply on-line please visit: www.dundee.ac.uk/jobs. If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack. Please quote reference number LS0351. The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community. The University of Dundee is a Scottish Registered Charity, No. SC015096. Dr David Robinson Structural Biologist Drug Discovery Unit Division of Biological Chemistry and Drug Discovery College of Life Sciences James Black Centre University of Dundee
