Hi Raji,
For case #2, an example is calmodulin, which displays remarkable
acrobatics across crystal forms, and +/- ligand.
I look forward to reading about the extreme cases that satisfy
case #1 on the list!
Ho
Ho Leung Ng
University of Hawaii at Manoa
Assistant Professor, Department of Chemistry
h...@hawaii.edu
On Fri, Mar 8, 2013 at 2:00 PM, CCP4BB automatic digest system
<lists...@jiscmail.ac.uk> wrote:
> Date: Fri, 8 Mar 2013 14:38:01 -0500
> From: Raji Edayathumangalam <r...@brandeis.edu>
> Subject: Need specific molecular replacement test cases
>
> Hello Everyone,
>
> I am looking for two specific test cases (below) and appreciate anyone
> pointing me to known structures/examples for the same.
>
> (1) For a successful case of molecular replacement in which the search
> model has an overall sequence identity to the target in the twilight zone
> or worse (25% or less).
>
> (2) A case in which the search and target models share 80-100% sequence
> identity but where conformational changes in the target relative to the
> search model prevented a successful MR solution.
>
> Many thanks.
> Raji
>
> --
> Raji Edayathumangalam
> Instructor in Neurology, Harvard Medical School
> Research Associate, Brigham and Women's Hospital
> Visiting Research Scholar, Brandeis University
