Hi Yarrow, You can use the likes of areaimol to calculate the surface accessible area, with or without accounting for crystal symmetry: http://www.ccp4.ac.uk/html/areaimol.html
There are other alternatives, but I hope that helps, Rob On 8 Sep 2012, at 00:37, Yarrow Madrona wrote: > I have a buried active site and would like to determine if there is room > for a water molecule in various mutants. Does anyone know of a good > program to calculate this? I have heard of GRID and VOID but have never > used them. > > Thanks. > > > -- > Yarrow Madrona > > Graduate Student > Molecular Biology and Biochemistry Dept. > University of California, Irvine > Natural Sciences I, Rm 2403 > Irvine, CA 92697
