A recently funded project entitled "New Targets to Address Old Problems
in Oncology" is recruiting personell. The goal of the project is to
assess the feasibility of driving cancer cells into apoptosis by
inhibiting transcription coupled repair (TCR) of DNA. The person will
form part of a team of 3 working to develop small molecule inhibitors of
the Cockayne Syndrome B (CSB) protein that initiates TCR. The project is
a collaboration with the group of Prof. Leon Mullenders at the Leiden
University Medical Center, while two companies ZoBio and Prestwick
Chemicals, will provide support in the area of chemistry. My group will
be responsible for the discovery and validation of small molecules that
bind to and inhibit CSB. We will then use structural biology to enhance
the potency of the CSB ligands. The group of Prof. Mullenders will
develop in vitro and in vivo assays to determine the mode of action of
the inhibitors and help to achieve the ultimate goal, that is to
determine whether inhibition of CSB selectively drives cancer cells into
apoptosis. We are currently seeking an an experienced, motivated
post-Doc for three years with experience in X-ray crystallography.
To apply please send a letter of motivation, your CV and the names and
contact information of preferably 3 people willing to provide references
g.sie...@chem.leidenuniv.nl <mailto:g.sie...@chem.leidenuniv.nl>.
--
Gregg Siegal
Gorlaeus Laboratory
Leiden University
Einsteinweg 55
2300-RA Leiden
The Netherlands
Phone (+31) 71 527 4543
Mob (+31) 6 3956 4439
Fax (+31) 71 527 4609
email: g.sie...@chem.leidenuniv.nl
http://protchem.lic.leidenuniv.nl/
