While it's not a review on protein binding sites, the following review might be helpful in understanding its chemistry:
Holloway & Melnik (1995) Main Group Met. Chem. 451-585. Also, David Giedroc has written a couple of useful reviews that include discussions of cadmium binding proteins. Cadmium is kind of a generalist. It will bind to sites tailored for calcium, manganese and zinc quite readily, accepting a wide range of protein ligands. Biologically, most cadmium-specific proteins use softer ligands (cysteines) since other metals are relatively less attracted to those sites. You may see some coordination positions taken up by chloride if you have a high enough concentration in your buffer. Good luck, Arthur On Aug 26, 2011, at 6:54 AM, Sandeep wrote: > Hi, > > I crystallised a protein in the presence of Calcium, Cobalt, and Cadmium and > determined its structure. It turns out that I see several metal sites in the > structure, mostly cadmiums. Is there any information published (preferably a > review) which summarises data on cadmium sites in proteins such as for > example the possible coordination numbers of cadmium, distances, type of side > chains found to coordinate with cadmium, etc.? I could extract all this from > the PDB, but a nice review would be simpler to start with. > > Thank you in advance for your help > > Sandeep >
