Hello Sandeep, I have been in this situation many times before but with different metal ions.. I have found papers published by Marjorie M Harding very useful in such situations. In fact, there are lots of information on-line on which is available here (including all the references for his papers):
*METAL COORDINATION SITES IN PROTEINS* * * http://tanna.bch.ed.ac.uk/ http://tanna.bch.ed.ac.uk/qg3.htm http://tanna.bch.ed.ac.uk/newtargs_06.html You will at least find information for Ca and Co here for sure. All the best Simanshu On Fri, Aug 26, 2011 at 10:21 AM, Partha Chakrabarti <ppc...@gmail.com>wrote: > Hi Sandeep, if someone sends one, kindly share the references. > > In general, Ca2+ could have more Asp, Asn kind of coordination and > distorted pentagonal bipyramidal geometry with waters (about 2.5A), Cd can > also have S- since it is softer, I guess Co might have N/O/S (i.e all three > with paired electrons). An inorganic chemistry textbook like Greenwood & > Earnshaw or Cotton & Wilkinson could be handy.. or a bioinorganic chemistry > book. > > HTH, > Partha > > > > > On Fri, Aug 26, 2011 at 7:24 PM, Sandeep <s.talapa...@beatson.gla.ac.uk>wrote: > >> Hi, >> >> I crystallised a protein in the presence of Calcium, Cobalt, and Cadmium >> and determined its structure. It turns out that I see several metal sites in >> the structure, mostly cadmiums. Is there any information published >> (preferably a review) which summarises data on cadmium sites in proteins >> such as for example the possible coordination numbers of cadmium, distances, >> type of side chains found to coordinate with cadmium, etc.? I could extract >> all this from the PDB, but a nice review would be simpler to start with. >> >> Thank you in advance for your help >> >> Sandeep >> > > -- Dhirendra K Simanshu Memorial Sloan-Kettering Cancer Center Structural Biology Program New York, NY, USA 10065
