Hi Tim,

following this discussion, I was wondering how much sense it makes to use
TLS domains and experimental phases at the same time.

I guess both things are completely irrelevant. With using experimental phases you bring in more data. And with using TLS you simply use a more adequate model for ADPs. It's explained here:

http://www.phenix-online.org/newsletter/CCN_2010_07.pdf

starting page #24.

All the best!
Pavel.

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