Hi Justin,
may be I mis-understood your question, but can't anisotropic scale
factor that is the part of the total structure factor (as defined in
phenix.refine for example and most likely in the other programs):
Fmodel = scale_overall * exp(-h*U_overall*ht) * (Fcalc_atoms + k_sol *
exp(-B_sol*s^2) * Fmask)
take care of this (S. Sheriff & W.A. Hendrickson. Acta Cryst. (1987).
A43, 118-121. "Description of overall anisotropy in diffraction from
macromolecular crystals")?
For an example of how important to use anisotropic scale for anisotropy
correction, see slide #20 here:
http://phenix-online.org/presentations/neutron_japan_2009/phenix_japan_part1.pdf
Pavel.
On 9/1/09 7:35 AM, Justin Hall wrote:
Dear All;
I am working with a data set which is anisotropic. The resolution
limits are ~ 2.75 by 3.45 A. The I have integrated (using Mosflm) the
data out to 2.75 A, the data therefore includes a mix of real (I/sig
>>1) and imaginary (I/sig ~1) data past the 3.45 A resolution bin.
I am concerned that the presence of the poor quality data in the outer
shells will cause my good data to 2.75 A resolution to be down
weighted in refinement. Since anisotropic resolution limits do not
seem to be an option, are there other tools that would allow proper
weighting for this situation?
Cheers~
~Justin Hall
Oregon State University
